Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System

American Journal of Reproductive Immunology : AJRI
Satoshi YonedaShigeru Saito

Abstract

To examine the efficacy of the use of antibiotics in preterm labor (PTL) with intact membranes, after evaluating intra-amniotic microbes by our rapid and bacteria-free polymerase chain reaction (PCR) system. One hundred and four PTL patients before 32 weeks of gestation were recruited. Until 2012, antibiotics were empirically prescribed based on the clinical severity of PTL. Intra-amniotic microbes in stored samples were evaluated later by our newly established PCR system, and the efficacy of the use of antibiotics in PTL was evaluated. In the amniotic fluid (AF) microbe-negative patients (n = 67), antibiotic therapy significantly shortened the gestation period (P < 0.0001), whereas in the microbe-positive patients (n = 37), appropriate antibiotic therapy (proper antibiotic selection against identified AF microbes) was significantly associated with an increase in gestation period (P < 0.0001). Appropriate antibiotic therapy in PTL with intact membranes prolonged the gestation period.

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Citations

Mar 4, 2018·American Journal of Reproductive Immunology : AJRI·Nardhy Gomez-LopezChaur-Dong Hsu
Jan 10, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yohei MakiHiroshi Sameshima
Dec 15, 2017·The Journal of Obstetrics and Gynaecology Research·Satoshi YonedaShigeru Saito
Nov 13, 2018·Frontiers in Immunology·Derek MillerNardhy Gomez-Lopez
Dec 28, 2017·American Journal of Reproductive Immunology : AJRI·Noriko YonedaShigeru Saito
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Apr 29, 2020·American Journal of Obstetrics and Gynecology·Meredith A KelleherIrina Burd
Sep 25, 2021·Scientific Reports·Daichi UrushiyamaShingo Miyamoto

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