Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

The Cochrane Database of Systematic Reviews
Alex HorsleyRobert Lord

Abstract

Chronic pulmonary infection is a hallmark of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 18 closely-related species of gram-negative bacteria, are particularly difficult to treat. These infections may be associated with a fulminant necrotising pneumonia. Burkholderia cepacia complex bacteria are resistant to many common antibiotics and able to acquire resistance against many more. Following patient segregation in cystic fibrosis medical care, the more virulent epidemic strains are not as frequent, and new infections are more likely to be with less virulent environmentally-acquired strains. Although evidence-based guidelines exist for treating respiratory exacerbations involving Pseudomonas aeruginosa, these cannot be extended to Burkholderia cepacia complex infections. This review, which is an update of a previous review, aims to assess the available trial evidence for the choice and application of treatments for these infections. To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation and chronically infected with organisms of the Burkholderia cepacia complex. We searched t...Continue Reading

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Citations

Jun 14, 2019·The Cochrane Database of Systematic Reviews·Freddy FrostDilip Nazareth
Nov 13, 2019·Antimicrobial Agents and Chemotherapy·Mojgan Sabet, David C Griffith
Oct 12, 2018·Thorax·Nicola Jane RowbothamAlan Robert Smyth
Mar 6, 2019·Frontiers in Cellular and Infection Microbiology·Thaysa Leite TagliaferriHans-Peter Horz
Oct 12, 2018·Case Reports in Infectious Diseases·John Koo, Gregory D Deans

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