Antibiotic treatment in preterm labor and intact membranes: a randomized, double-blinded, placebo-controlled trial

The Journal of Maternal-fetal Medicine
E OyarzúnF Montiel

Abstract

Although an association between microbial invasion of amniotic cavity and preterm birth has been extensively demonstrated, there is conflicting evidence regarding the benefits of antibiotic therapy in patients with preterm labor and intact membranes. We attempted to assess the efficacy of amoxicillin and erythromycin on pregnancy outcome in those patients. A randomized, double-blinded, placebo-controlled trial was designed and implemented. A total of 196 patients with singleton pregnancies and preterm labor with intact membranes (22-36 weeks) were randomly allocated to receive either antibiotics or placebo, plus adjunctive parenteral tocolysis, and 173 patients (antibiotics group n = 83 vs. placebo group n = 90) completed the treatment. The overall prevalence of microbial invasion of the amniotic cavity was 5.2% (9/173). No significant difference between both groups was found in maternal outcomes, including duration of randomization-to-delivery interval, frequency of preterm delivery, and frequency of clinical chorioamnionitis and endometritis. Rate of cesarean section was significantly higher in the placebo group (28% vs. 12%). Regarding neonatal outcome, no significant difference was detected between both groups in neonatal d...Continue Reading

Citations

Apr 17, 2012·Infectious Diseases in Obstetrics and Gynecology·Akila SubramaniamAlan T Tita
May 14, 2010·Therapeutics and Clinical Risk Management·Olaleye Sanu, Ronald F Lamont
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Chong Jai KimYeon Mee Kim
Nov 15, 2001·Seminars in Perinatology·G Locksmith, P Duff
Jan 13, 2004·Clinics in Perinatology·Robert L Goldenberg, Jennifer Flatow Culhane
Mar 21, 2002·American Journal of Obstetrics and Gynecology·John M ThorpVic Hasselblad
Aug 25, 2001·Paediatric and Perinatal Epidemiology·R RomeroY M Kim
Sep 13, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alfredo OvalleJorge Figueroa
Oct 18, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·P FidelR Gomez
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·R J Sawdy, P R Bennett

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