PMID: 8589668Oct 1, 1995Paper

Antibiotic treatment induces an increase of the specific antibody levels in Brucella melitensis infected mice

FEMS Immunology and Medical Microbiology
S DomingoC Gamazo

Abstract

The effects of doxycycline (DOX) and streptomycin (SM) treatment of Brucella melitensis infected mice on humoral immune response were examined. In female BALB/c mice, DOX was administered at a dose of 50 mg/kg/12 h, for 21 or 45 consecutive days, alone or combined with SM (10 mg/kg/12 h) for 14 days. All treatments induced a significant increase in specific IgG levels (ELISA and CIEP) against LPS and cytosolic antigens of Brucella during treatment. This was not related with therapeutic failure or relapse since all treatments induced a significant reduction in the degree of infection.

References

Nov 1, 1990·Reviews of Infectious Diseases·W H Hall
Mar 1, 1989·Reviews of Infectious Diseases·P J van den Broek
Jan 1, 1987·Annales De L'Institut Pasteur. Microbiology·I MoriyónR Díaz
May 1, 1988·The Journal of Infectious Diseases·T PellicerF Gudiol
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J ArizaP Fernández-Viladrich
Sep 1, 1983·Reviews of Infectious Diseases·E J Young
Jul 1, 1980·Journal of Clinical Pathology·P W RossC G Cumming
May 1, 1994·Journal of Clinical Microbiology·E Díaz-AparicioI Moriyón
Aug 1, 1993·Veterinary Immunology and Immunopathology·J M BlascoR Díaz
Mar 1, 1954·The Medical Clinics of North America·T E WOODWARDR T PARKER

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Citations

Apr 17, 2012·Veterinary Research·María-Jesús GrillóEdgardo Moreno
Feb 26, 2019·Infection and Immunity·Ricardo Mora-CartínEdgardo Moreno
May 4, 1999·Clinical and Diagnostic Laboratory Immunology·R A BowdenP C Baldi

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