Antibiotic treatment of acute bronchitis in smokers: a systematic review

Journal of General Internal Medicine
Jeffrey A Linder, Ida Sim

Abstract

Community physicians in the United States prescribe antibiotics to 80% to 90% of smokers with acute bronchitis. We performed a systematic review of the literature to determine the efficacy of antibiotics for smokers with acute bronchitis. A medline search was done using the keywords bronchitis, cough, and antibiotics to identify English language articles published from January 1966 to September 2001. Randomized, placebo-controlled trials of antibiotics in previously healthy smokers and nonsmokers with acute bronchitis were included. For each study, we abstracted information on design, size, inclusion criteria, patient characteristics, and outcomes. Of 2,029 articles in the original search, 109 relevant articles were retrieved and reviewed. There have been no studies specifically addressing antibiotic use in smokers with acute bronchitis. Nine randomized, placebo-controlled trials of antibiotics have included 774 patients and over 276 smokers. Lack of subgroup reporting for smokers precluded meta-analysis. In 7 trials, smoking status did not predict or alter patients' response to antibiotics. In one trial, trimethoprim/sulfamethoxazole resulted in less-frequent cough overall, but not among smokers. In another trial, erythromycin...Continue Reading

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Citations

Aug 31, 2012·Epilepsy Research and Treatment·Vadim Beletsky, Seyed M Mirsattari
Oct 14, 2005·Journal of the American Medical Informatics Association : JAMIA·Jeffrey A LinderBlackford Middleton
May 28, 2004·Comprehensive Therapy·Fernando J Martinez
Oct 10, 2006·Wiener klinische Wochenschrift·Christoph Wenisch
Dec 26, 2015·American Journal of Preventive Medicine·Michael B SteinbergCristine D Delnevo
May 27, 2004·Journal of the American Geriatrics Society·Michael A SteinmanRalph Gonzales
Jun 6, 2009·The American Journal of Emergency Medicine·Sherrie L AspinallMichael J Fine

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