PMID: 2097703Jan 1, 1990Paper

Antibiotic uptake and transport by bacteria

Scandinavian Journal of Infectious Diseases. Supplementum
D M Livermore

Abstract

A few antibiotics, e.g. polymyxins, disorganize the bacterial wall. For most, however, the wall is an obstacle to be crossed. The extent of this barrier varies with the target to be reached, the drug and the bacterial species. Staphylococci and streptococci have only capsular material and peptidoglycan external to the cytoplasmic membrane (CM). These components afford little shielding and agents with targets on the outer surface of the CM (e.g. vancomycin and beta-lactams) have unhindered target access. Antibiotics with cytoplasmic or ribosomal targets must however cross the CM, usually by active transport. Mycobacteria have outer barriers beyond the CM, as do Gram-negative species. The latter organisms have an outer membrane (OM) located externally to the peptidoglycan and CM. Being hydrophilic, most antibiotics cross the OM by passive diffusion through pores composed of 'porin' proteins. Uptake varies with the drug's charge, size and hydrophilicity, also with the number of pores. Antibiotics larger than 800 D are excluded. Once across the OM, the antibiotics have access to the CM, which must be crossed by those with ribosomal or cytoplasmic targets. Resistance can arise by porin loss, or by loss of an active uptake pathway in...Continue Reading

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.