Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Xu WangJohan Auwerx

Abstract

Recently, several studies have demonstrated that tetracyclines, the antibiotics most intensively used in livestock and that are also widely applied in biomedical research, interrupt mitochondrial proteostasis and physiology in animals ranging from round worms, fruit flies, and mice to human cell lines. Importantly, plant chloroplasts, like their mitochondria, are also under certain conditions vulnerable to these and other antibiotics that are leached into our environment. Together these endosymbiotic organelles are not only essential for cellular and organismal homeostasis stricto sensu, but also have an important role to play in the sustainability of our ecosystem as they maintain the delicate balance between autotrophs and heterotrophs, which fix and utilize energy, respectively. Therefore, stricter policies on antibiotic usage are absolutely required as their use in research confounds experimental outcomes, and their uncontrolled applications in medicine and agriculture pose a significant threat to a balanced ecosystem and the well-being of these endosymbionts that are essential to sustain health.

References

Dec 1, 1979·Zeitschrift Für Naturforschung. Section C: Biosciences·C CocitoO Ciferri
Jul 1, 1976·The Biochemical Journal·C J Leaver, M A Harmey
Jan 1, 1988·Annual Review of Cell Biology·G Attardi, G Schatz
Dec 7, 1973·Biochimica Et Biophysica Acta·H de VriesA M Kroon
Jan 1, 1969·Calcified Tissue Research·H M Frost
May 25, 1971·Biochemistry·J C Mao, E E Robishaw
Oct 5, 1966·Biochemical and Biophysical Research Communications·G D Clark-Walker, A W Linnane
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·I Chopra
Oct 1, 1993·Trends in Biochemical Sciences·K Verner
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·A KistnerH Bujard
May 1, 1997·The Journal of Antimicrobial Chemotherapy·C CocitoP Vannuffel
Aug 28, 1998·Science·D R Green, J C Reed
Mar 5, 1999·Science·D C Wallace
Apr 2, 1999·Antimicrobial Agents and Chemotherapy·M P Mingeot-LeclercqP M Tulkens
Feb 13, 2001·Plant Physiology·J MüllerA Wiemken
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·I Chopra, M Roberts
May 8, 2002·Nature Reviews. Molecular Cell Biology·Constance E Brinckerhoff, Lynn M Matrisian
Jul 31, 2002·Annual Review of Phytopathology·Patricia S McManusAlan L Jones
Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·William MartinDavid Penny
Jun 25, 2003·Chemosphere·Luciana MiglioreMaurizio Fiori
Jan 22, 2004·Nature Reviews. Genetics·Jeremy N TimmisWilliam Martin
May 22, 2004·The Biochemical Journal·Abhijit MukhopadhyayHenry Weiner
Nov 25, 2005·The New England Journal of Medicine·Alex SorianoJosep Mensa
May 26, 2006·Antimicrobial Agents and Chemotherapy·E E McKeeT A Marks
Jun 30, 2007·Annual Review of Genetics·Adrian Reyes-PrietoDebashish Bhattacharya
Sep 7, 2007·Cell·Michael A KohanskiJames J Collins
Nov 6, 2008·Annual Review of Genetics·Stephan EberhardFrancis-André Wollman
Nov 18, 2008·Annals of Botany·Nelson J M SaiboMaria Margarida Oliveira
Nov 26, 2008·Molecular Cell·Rebeca Acín-PérezJose Antonio Enriquez
Feb 26, 2010·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·X WeiM H Wong
Oct 12, 2010·Environmental Science and Pollution Research International·Xiujie XieYanyu Bao
Nov 26, 2010·Archives of Environmental Contamination and Toxicology·Derek G HillisPaul K Sibley

❮ Previous
Next ❯

Citations

Jun 17, 2016·ELife·Xiaoyan Robert BaoVamsi K Mootha
Jul 16, 2016·The Journal of Physiology·Aafke W F Janssen, Sander Kersten
Sep 23, 2016·Future Medicinal Chemistry·Samuel A McKie
Sep 25, 2017·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Peter Kramer, Paola Bressan
Jul 10, 2018·Plant & Cell Physiology·Marco E GudiñoFederico Navarro-García
Mar 7, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yan HanXiangsheng Chen
Feb 8, 2019·Current Pharmaceutical Biotechnology·Taj Yeruva, Chi H Lee
Feb 26, 2020·Physiologia Plantarum·James B Y H BehrendorffMathias Pribil
Oct 29, 2019·The Plant Journal : for Cell and Molecular Biology·Omer MurikOren Ostersetzer-Biran
Apr 29, 2018·Journal of Food and Drug Analysis·Lin-Lin ChenLi-Heng Pao
Feb 17, 2017·Frontiers in Cellular and Infection Microbiology·Yang XingYang Qian
May 2, 2020·Nature Communications·Nikolay P KandulOmar S Akbari
Jan 31, 2021·Nature Chemistry·Shuaidong HuoAndreas Herrmann
Jan 26, 2020·Biochemical and Biophysical Research Communications·Tomohiro MinakawaJun K Yamashita
Mar 26, 2021·Cell Reports Medicine·Polina MamoshinaAlfonso Bueno-Orovio
May 25, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Fernando Baquero
Oct 6, 2018·The Science of the Total Environment·Maria Alexandra BighiuJakob Ottoson
Aug 7, 2021·Biomolecules·Juan M Suárez-RiveroJosé A Sánchez-Alcázar
Nov 5, 2021·The CRISPR Journal·Nikolay P KandulOmar S Akbari
Nov 14, 2021·Environmental Science and Pollution Research International·Mansi AprejaPrince Sharma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.