Antibiotic use and misuse in the neonatal intensive care unit.

Clinics in Perinatology
Nidhi TripathiP Brian Smith

Abstract

Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common neonatal pathogens are susceptible to narrow-spectrum antibiotics. The choice of antibiotic and duration of empiric treatment are strongly associated with center-based risk factors. Clinicians should treat with short courses of narrow-spectrum antibiotics whenever possible, choosing the antibiotics and treatment duration to balance the risks of potentially untreated sepsis against the adverse effects of treatment in infants with sterile cultures.

References

Jul 25, 1991·The New England Journal of Medicine·M HackE Borawski
Jun 7, 1973·The New England Journal of Medicine·A PhilipsonD Charles
Feb 1, 1993·The Pediatric Infectious Disease Journal·W A BonadioD Isaacman
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·I H GewolbP Panigrahi
Apr 18, 2000·Lancet·P de ManJ N van den Anker
Dec 12, 2001·The Pediatric Infectious Disease Journal·L SaimanUNKNOWN National Epidemiology of Mycoses Study Group
Jul 26, 2002·The New England Journal of Medicine·Barbara J StollW Kenneth Poole
Jun 7, 2003·The Pediatric Infectious Disease Journal·Mary C OttoliniMartin G Ottolini
Sep 27, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Leandro Cordero, Leona W Ayers
Feb 27, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Daniel K BenjaminReese H Clark
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Barbara J StollUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Aug 3, 2006·Pediatrics·C Michael CottenUNKNOWN National Institute for Child Health and Human Development Neonatal Research Network
Feb 19, 2009·Infectious Diseases in Obstetrics and Gynecology·Mei L CastorRuth Lynfield
Feb 24, 2010·Antimicrobial Agents and Chemotherapy·Anouk E MullerMeindert Danhof
Mar 17, 2010·Pediatrics·Gil KlingerUNKNOWN Israel Neonatal Network
Jun 30, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·B Muller-PebodyUNKNOWN iCAP Group (Improving Antibiotic Prescribing in Primary Care)
Apr 15, 2011·The Journal of Pediatrics·Vanaja N AlexanderMatthew J Bizzarro
Apr 27, 2011·Pediatrics·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jul 26, 2011·The Journal of Pediatrics·Venkata S KuppalaKurt R Schibler

❮ Previous
Next ❯

Citations

Sep 14, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·C TziallaM Stronati
May 27, 2014·Infectious Disease Clinics of North America·Joseph B Cantey, Sameer J Patel
Jun 9, 2015·Paediatrics and International Child Health·Uduak A OkomoKalifa Bojang
Mar 10, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chryssoula TziallaMauro Stronati
Jun 17, 2016·Iranian Journal of Pediatrics·Seyyed-Abolfazl AfjehFatemeh Esmaili
Aug 29, 2013·BioMed Research International·Haining YuanBairong Shen
Apr 19, 2015·Italian Journal of Pediatrics·Chryssoula TziallaGiovanni Corsello
Apr 4, 2015·Pediatric Clinics of North America·Roberto Parulan Santos, Debra Tristram
Jan 9, 2015·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Martina Kraus-HaasArne Simon
Jul 27, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nneka I NzegwuMatthew J Bizzarro
Feb 23, 2013·Neonatology·Andrea S WeintraubAnnemarie Stroustrup
May 24, 2018·Paediatrics and International Child Health·Aline FuchsJohannes N Van Den Anker
Oct 11, 2014·Pediatric Research·Michael P ShermanVictoria Niklas
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Brenda N G SilvaReinaldo Salomão
May 25, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Carlos FajardoAndrei Harabor
Mar 2, 2018·Clinical Microbiology Reviews·Mridu SinhaStephanie I Fraley
Oct 31, 2015·PloS One·Sara I V C LimaIvonete B Araujo
Apr 4, 2018·The Pediatric Infectious Disease Journal·Maria S RuedaUNKNOWN NEOLACTO Research Group
Jan 19, 2019·Current Pediatric Reviews·Despoina Gkentzi, Gabriel Dimitriou
Jun 30, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Despoina GkentziUNKNOWN Neonatal Infection Surveillance Network in Greece
Jan 24, 2013·The Pediatric Infectious Disease Journal·Arne Simon, Tobias Tenenbaum
Jul 28, 2018·European Journal of Pediatrics·Evelien Hilde VerstraeteStijn Blot
Jan 30, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Cynthia L GongJoel W Hay
Mar 27, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Seth J LangstonAlison Chu
Feb 1, 2014·Metabolomics : Official Journal of the Metabolomic Society·Lindsey E Romick-RosendaleMichael A Kennedy
Aug 2, 2020·NeoReviews·Augusto SolaUNKNOWN members of the 10th SIBEN Clinical Consensus
Dec 7, 2019·Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen
Jan 31, 2021·Maternal Health, Neonatology and Perinatology·Alaina K PylePablo J Sánchez
Jun 11, 2019·Journal of Pharmaceutical and Biomedical Analysis·Sophie MagréaultEvelyne Jacqz-Aigrain
May 11, 2021·Der Gynäkologe·Arne SimonSascha Meyer
May 18, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen
May 18, 2021·The Cochrane Database of Systematic Reviews·Steven Kwasi KorangJanus C Jakobsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.