Antibiotic use and serious complications following acute otitis media and acute sinusitis: a retrospective cohort study.

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Rebecca Cushen, Nick A Francis

Abstract

Most people with acute otitis media (AOM) and acute sinusitis (AS) do not benefit from antibiotics, and GPs are under increasing pressure to reduce antibiotic prescribing. Concern about the risk of complications can drive unnecessary prescribing. To describe the incidence of serious complications following AOM and AS, and to determine whether antibiotics are protective. This was a retrospective cohort study using the Clinical Practice Research Datalink database to identify patients diagnosed in general practice with AOM or AS between 1 January 1982 and 31 December 2012. The incidence of brain abscess and acute mastoiditis following AOM, and of brain abscess and orbital cellulitis following AS, were calculated, as was the association between antibiotics and the development of these complications and numbers needed to treat (NNT). The incidence of brain abscess and acute mastoiditis following AOM were 0.03 (95% confidence interval [CI] = 0.01 to 0.20) and 5.62 (95% CI = 4.81 to 6.56) per 10 000 AOM episodes, respectively. The incidence of brain abscess and orbital cellulitis following AS was 0.11 (95% CI = 0.05 to 0.26) and 1.50 (95% CI = 1.17 to 1.90) per 10 000 AS episodes, respectively. Antibiotic prescription for AOM was asso...Continue Reading

References

May 11, 2005·Surgical Neurology·Furen XiaoJui-Chang Tsai
Dec 11, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Luke T CondonStephen L Atkin
Jan 19, 2010·British Journal of Clinical Pharmacology·Emily HerrettAndrew J Hall
Oct 19, 2012·The Cochrane Database of Systematic Reviews·Marieke B LemiengreAn I M De Sutter
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Roderick P VenekampMaroeska M Rovers
Jan 31, 2014·Neurology·Matthijs C BrouwerDiederik van de Beek
Oct 29, 2015·PloS One·Cristian Gonzalez-GonzalezUNKNOWN GREPHEPI Group
Mar 1, 2018·The Journal of Antimicrobial Chemotherapy·Koen B PouwelsTimo Smieszek
Mar 1, 2018·The Journal of Antimicrobial Chemotherapy·F Christiaan K DolkTimo Smieszek
Jan 12, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Pratama Novan Y IUNKNOWN Suharjono

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Citations

Nov 20, 2020·BMJ : British Medical Journal·Roderick P VenekampAlastair D Hay
Mar 9, 2021·Journal of Family Medicine and Primary Care·Mohammed AlsuhaibaniAqeel Alaqeel

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