Antibiotic use from conception to diagnosis of child leukaemia as compared to the background population: A nested case-control study

Pediatric Blood & Cancer
Kim O Gradel, Linda Kaerlev

Abstract

The role of infection in the aetiology of childhood leukaemia is unknown. We used prescriptions of antibiotics from Danish pharmacies as a proxy measure for the occurrence of infections. We investigated the association between exposure to antibiotics, from conception to leukaemia diagnosis, and the risk of leukaemia. Incident cases of leukaemia among children in Denmark, 1995-2008, with mothers having their earliest conception date in 1995, were individually matched to population controls by age, sex and municipality. Conditional logistic regression analyses assessed antibiotic redemptions in different time periods from conception up to 6 months before the diagnoses of all leukaemia types, acute lymphoblastic leukaemia [ALL] and ALL in 2- to 5-year-old children, adjusting for several potential confounders. A total of 120/360 (33.3%) leukaemia mothers and 1,081/3,509 (30.8%) control mothers redeemed antibiotics during pregnancy (P = 0.32). For children, the equivalent numbers were 276 (76.7%) and 2,665 (75.9%) (P = 0.76). Histograms of antibiotic redemptions showed no temporal differences between leukaemia mothers/children and controls, which was confirmed in adjusted regression analyses (OR [95% CI]: 1.02 [0.75-1.38]). Only ant...Continue Reading

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Citations

Apr 22, 2015·Pediatric Blood & Cancer·Gary Dahl, Joseph Wiemels
Oct 26, 2016·Genes, Chromosomes & Cancer·Kristina Karrman, Bertil Johansson
Oct 30, 2020·Blood·Anindita Roy
May 22, 2021·American Journal of Epidemiology·Sarah HjorthHedvig Nordeng

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