Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship

PloS One
Getachew AlemkereEphrem Engidawork

Abstract

Malpractice and excess use of antimicrobials have been associated with multiple costs, including the development of resistant bacteria, which has become a threat to the human health. The aim of this study, therefore, was to assess the antibiotic use practice and to identify predictors of hospital outcome to uncover targets for stewardship. An Institution-based prospective observational study was performed from 9 April to 7 July 2014 in the internal medicine wards of Tikur Anbessa Specialized Hospital. Patients with suspected systemic bacterial infections during this period were strictly followed and data were abstracted using data abstraction format. Descriptive statistics and binary logistic regression were used for statistical analysis. About half of the attended patients had suspected systemic bacterial infections, in which pneumonia is the most common. Cephalosporins were the most widely prescribed class of drugs in all the wards. Initial antibiotics were empiric in almost all of the cases. About 28% of the ward and 59% of the ICU patients died during the in-hospital stay. The mean length of stay (LoS) was 18.5+12.2 in the wards and 8.9+4.9 days in the ICU. Whilst digestive disease (AOR = 6.94, 95% CI: 2.24, 21.49), differe...Continue Reading

References

Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor L YuUNKNOWN International Pneumococcal Study Group
Oct 15, 2005·Clinical Microbiology Reviews·Conan MacDougall, Ron E Polk
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy H DellitUNKNOWN Society for Healthcare Epidemiology of America
Jan 30, 2007·BMC Infectious Diseases·Philip C HillRichard A Adegbola
Sep 11, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rebecca R RobertsRobert A Weinstein
Jun 10, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neil GuptaAlexander J Kallen
Aug 20, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D C LyeL-Y Hsu
Dec 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Javier FernándezVicente Arroyo
Apr 17, 2012·Annals of Rehabilitation Medicine·Hye Jin JangHyung-Ik Shin
May 23, 2012·BMC Pulmonary Medicine·Isabelle Suter-WidmerUNKNOWN ProHOSP Study Group
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 28, 2013·Critical Care Medicine·David F GaieskiBrendan G Carr
Sep 17, 2013·International Journal of Environmental Research and Public Health·Chang-Ro LeeSang Hee Lee
Jun 22, 2014·BMC Infectious Diseases·Caroline M A van den BoschUNKNOWN Dutch Sepsis QI expert panel
Oct 1, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Caroline M A van den BoschMarlies E J L Hulscher
May 8, 2015·Global Journal of Health Science·Ali Asghar GhodsEhsan Zarei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.