Antibiotics commonly used to treat mastitis and respiratory burst of bovine polymorphonuclear leukocytes

Journal of Dairy Science
D HoebenR Heyneman

Abstract

The in vitro effects of six doses (2 x 10(-3) to 2 x 10(-8) M) of antimicrobial drugs that are frequently used in udder infusions on the capacity of bovine blood polymorphonuclear neutrophilic leukocytes to generate reactive oxygen species were studied by the measurement of luminol-dependent chemiluminescence after stimulation with phorbol 12-myristate 13-acetate. All drugs, except cloxacillin, significantly decreased chemiluminescence at the highest dose. Doxycyline induced the most severe inhibition, followed by neomycin and dihydrostreptomycin. The effect of ampicillin was due to the scavenging of reactive oxygen species and interactions with luminol. The inhibition observed with oleandomycin, neomycin, lincomycin, and dihydrostreptomycin was not due to direct effects on the production of oxidative metabolites but rather to interference with other components involved in the production of light, such as interference with the interaction between luminol and the myeloper-oxidase-H2O2-halide system. The deleterious effects of doxycycline can be explained by several factors: decreased production of superoxide, yellow color, the scavenging of reactive oxygen species, and Ca2+ chelating effect. In conclusion, the results of this st...Continue Reading

References

Jan 1, 1979·Journal of Dairy Science·M J PaapeR E Pearson
Mar 1, 1989·Reviews of Infectious Diseases·P J van den Broek
Nov 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·G Gillissen
Dec 1, 1988·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·H NagahataH Noda
May 1, 1987·Antimicrobial Agents and Chemotherapy·G Briheim, C Dahlgren
Jun 1, 1983·Antimicrobial Agents and Chemotherapy·A FiettaG G Grassi
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·J GletteC O Solberg
Jan 1, 1982·Infection and Immunity·L R DeChatelet, P S Shirley
Jul 1, 1981·Antimicrobial Agents and Chemotherapy·W D WelchL D Thrupp
Dec 1, 1982·The Journal of Antimicrobial Chemotherapy·J P Siegel, J S Remington
Nov 1, 1981·The Journal of Antimicrobial Chemotherapy·H Gnarpe, J Belsheim
May 1, 1993·Antimicrobial Agents and Chemotherapy·M R GuntherM S Cohen
May 1, 1997·Veterinary Immunology and Immunopathology·D HoebenR Heyneman
Aug 13, 1997·European Journal of Pharmacology·D HoebenC Burvenich

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Citations

Jul 2, 2010·American Journal of Physiology. Cell Physiology·Michael O GriffinFrancisco Villarreal
Jan 8, 2008·Journal of Veterinary Pharmacology and Therapeutics·M MutinatiR L Sciorsci

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