Antibiotics: effect on cryopreserved-thawed human sperm motility in vitro

Fertility and Sterility
K KingA King

Abstract

To analyze the motility and fertilizing capacity of sperm treated with different antibiotics. Prospective comparative study. Clinical and academic research environment. Pooled cryopreserved donor sperm (n = 14). Sperm were washed with Percoll and resuspended in HEPES-buffered human tubal fluid medium containing either amoxicillin, ofloxacin, ciprofloxacin hydrochloride, nitrofurantoin monohydrate, doxycycline hyclate, cefuroxime axetil, or control medium. Sperm kinematic and fertilizing parameters. Sperm hyperactivation was decreased in physiologic concentrations of ciprofloxacin hydrochloride and doxycycline hyclate over the course of 48 hours. At pharmacologic concentrations, ciprofloxacin hydrochloride, cefuroxime axetil, and nitrofurantoin monohydrate adversely affected motility with decreased rapid progression. Cessation of motility occurred in cefuroxime axetil and nitrofurantoin monohydrate. Sperm hyperactivation was also absent. Cefuroxime axetil decreased the percentage of intact acrosomes. In contrast, physiologic doses of ciprofloxacin hydrochloride or ofloxacin enhanced sperm fertilizing capacity. Ciprofloxacin affected hyperactivation by altering membrane properties, whereas doxycycline inhibited the capacitation p...Continue Reading

References

Feb 1, 1991·Fertility and Sterility·P N SchlegelF F Marshall
Apr 22, 1967·Nature·R J Ericsson, V F Baker
Mar 1, 1995·The Journal of Urology·K L CrottyD E Neal

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Citations

Sep 23, 2014·Animal Reproduction Science·Alessia GloriaAugusto Carluccio
Apr 30, 2005·Journal of Medical Primatology·L Hernández-LópezP L Nayudu
Jan 18, 2005·Revista do Hospital das Clínicas·Fábio Firmbach PasqualottoSami Arap
Sep 22, 2021·Tropical Animal Health and Production·Ufuk Mercan YücelBarış Atalay Uslu

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