Antibiotics for exacerbations of chronic obstructive pulmonary disease

The Cochrane Database of Systematic Reviews
Felix Sf RamNeil C Barnes

Abstract

Most patients with an exacerbation of chronic obstructive pulmonary disease (COPD) are treated with antibiotics. However the value of their use remains uncertain. Some controlled trials of antibiotics have shown benefit (Berry 1960; Pines 1972) while others have not (Elmes 1965b; Nicotra 1982). To conduct a systematic review of the literature estimating the value of antibiotics in the management of acute COPD exacerbations. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 4, 2005); MEDLINE (1966 to December 2005); EMBASE (1974 to December 2005); Web of Science (December 2005), and other electronically available databases. Randomised controlled trials (RCTs) in patients with acute COPD exacerbations comparing antibiotic (for a minimum of five days) and placebo. Data were analysed using Review Manager software. Continuous data were analysed using weighted mean differences (WMD) and 95% confidence intervals (CI). Relative risks (RR) (and 95% CI) were calculated for all dichotomous data. Where appropriate, number needed to treat to benefit (NNT) and 95% CI were calculated. Eleven trials with 917 patients were included. Ten trials used increased cough, sputum volume and purulence d...Continue Reading

Citations

Jan 13, 2010·Lung·Joshua D Farkas, Harold L Manning
Jun 2, 2006·Thorax·R Rodríguez-Roisin
Dec 13, 2007·Proceedings of the American Thoracic Society·Fernando J Martinez
Sep 13, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Victoria BeasleyPatrick Mallia
Mar 9, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Ann R FalseyEdward E Walsh
Jul 23, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Ho Ii YoonChul-Gyu Yoo
Feb 14, 2008·International Journal of Chronic Obstructive Pulmonary Disease·Alfredo PotenaAlberto Papi
Mar 30, 2016·Current Neurology and Neuroscience Reports·Jessalyn K HolodinskyMichael D Hill
Dec 11, 2007·Microbes and Infection·Elena RonanderKristian Riesbeck
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Daniela J VollenweiderMilo A Puhan
Apr 3, 2016·The European Respiratory Journal·Carine Gomez, Pascal Chanez
Apr 9, 2008·American Journal of Respiratory and Critical Care Medicine·William MacNee
May 14, 2009·Clinical Medicine : Journal of the Royal College of Physicians of London·Irem Patel
Oct 30, 2018·The Cochrane Database of Systematic Reviews·Daniela J VollenweiderMilo A Puhan
Aug 16, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Clarice Y TangFelicity C Blackstock
Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Johannes M A DanielsWim G Boersma

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