Aug 15, 2013

Antibiotics for preventing complications in children with measles

The Cochrane Database of Systematic Reviews
Sushil K Kabra, Rakesh Lodha

Abstract

Measles is the leading killer among vaccine-preventable diseases; it is responsible for an estimated 44% of the 1.7 million vaccine-preventable deaths among children annually. To assess the effects of antibiotics given to children with measles to prevent complications and reduce pneumonia, other morbidities and mortality. We searched CENTRAL 2013, Issue 4, MEDLINE (1966 to May week 4, 2013) and EMBASE (1980 to May 2013). Randomised controlled trials (RCTs) and quasi-RCTs comparing antibiotics with placebo or no treatment, to prevent complications in children with measles. Two review authors independently extracted data and assessed trial quality. Seven trials with 1263 children were included. The methodological quality of most studies was poor. Only two studies were randomized, double-blind trials. There was variation in antibiotics used, their doses, schedule and evaluation of outcome. Pooled study data showed that the incidence of pneumonia was lower in the treatment group compared to the control group. However, the difference was not statistically significant. Of the 654 children who received antibiotics, 27 (4.1%) developed pneumonia; while out of 609 children in the control group, 59 (9.6%) developed pneumonia (odds ratio ...Continue Reading

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Citations

Mentioned in this Paper

Bacterial Conjunctivitis
Meta-Analysis (Publications)
Spasmodic Croup
Bacteriocidal Agents
Antibiotic throat preparations
Antifungal Antibiotics, Topical
Transcription Initiation
Adverse Effects
Sulfathiazole
Antibiotics, Gynecological

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