Antibiotics for treating acute chest syndrome in people with sickle cell disease

The Cochrane Database of Systematic Reviews
Arturo J Martí-CarvajalJ M Knight-Madden

Abstract

The clinical presentation of acute chest syndrome is similar whether due to infectious or non-infectious causes, thus antibiotics are usually prescribed to treat all episodes. Many different pathogens, including bacteria, have been implicated as causative agents of acute chest syndrome. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from acute chest syndrome. This is an update of a Cochrane review first published in 2007, and previously updated in 2013. To determine whether an empirical antibiotic treatment approach (used alone or in combination):1. is effective for acute chest syndrome compared to placebo or standard treatment;2. is safe for acute chest syndrome compared to placebo or standard treatment;Further objectives are to determine whether there are important variations in efficacy and safety:3. for different treatment regimens,4. by participant age, or geographical location of the clinical trials. We searched The Group's Haemoglobinopathies Trials Register, which comprises references identified from comprehe...Continue Reading

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Citations

Aug 2, 2018·The Cochrane Database of Systematic Reviews·Patricia M FortinLise J Estcourt
Sep 19, 2019·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalJennifer M Knight-Madden

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