Antibiotics in the clinical pipeline in October 2019.

The Journal of Antibiotics
Mark S Butler, David L Paterson

Abstract

The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR) bacteria, especially Gram-negative (G-ve) pathogens, is acknowledged as one of the world's most pressing health issues; however, the discovery and development of new, nontoxic antibacterials is not a straightforward scientific task, which is compounded by a challenging economic model. This review lists the antibacterials, β-lactamase/β-lactam inhibitor (BLI) combinations, and monoclonal antibodies (mAbs) first launched around the world since 2009 and details the seven new antibiotics and two new β-lactam/BLI combinations launched since 2016. The development status, mode of action, spectra of activity, lead source, and administration route for the 44 small molecule antibacterials, eight β-lactamase/BLI combinations, and one antibody drug conjugate (ADC) being evaluated in worldwide clinical trials at the end of October 2019 are described. Compounds discontinued from clinical development since 2016 and new antibacterial pharmacophores are also reviewed. There has been an increase in the number of early stage clinical candidates, which has been fueled by antibiotic-focused funding agencies; however, there is still a significant gap in the ...Continue Reading

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT02324335
NCT01987895
NCT01983683
NCT01551004
NCT02106338
NCT02751424
NCT01904318
NCT01803035
NCT03295266
NCT03259087

Software Mentioned

TenNor
AiCuris
Cipla
Tetraphase
Infectex
AntibioTx

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