Antibiotics versus placebo for acute bacterial conjunctivitis

The Cochrane Database of Systematic Reviews
A Sheikh, B Hurwitz

Abstract

There are concerns about whether antibiotic therapy confers significant clinical benefit in the treatment of acute bacterial conjunctivitis. The aim of this review was to assess the benefit and harm of antibiotic therapy in the management of acute bacterial conjunctivitis. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register), MEDLINE, EMBASE, SIGLE, NRR, PubMed and the reference lists of identified trial reports. We used the Science Citation Index to look for articles that cited the relevant studies, and we contacted investigators and pharmaceutical companies for information about additional trials. We included double masked randomised controlled trials in which any form of antibiotic treatment had been compared with placebo in the management of acute bacterial conjunctivitis. This included topical, systemic and combination (for example, antibiotics and steroids) antibiotic treatments. One author extracted data and the accuracy was checked by a second author. This review includes five trials which randomised a total of 1034 participants. One further trial is currently 'awaiting assessment'. This has been published in abstract form and has ye...Continue Reading

Citations

Jun 10, 2009·Antimicrobial Agents and Chemotherapy·Wolfgang HaasTimothy W Morris
Sep 26, 2013·BioMed Research International·Jayaraman KaliamurthyPhilip A Thomas
May 14, 2010·Clinical Ophthalmology·Timothy L ComstockJin-Zhong Zhang
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Aug 10, 2012·British Journal of Nursing : BJN·Paul M Rutter
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Sep 14, 2012·The Cochrane Database of Systematic Reviews·Aziz SheikhUlugbek Nurmatov
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