PMID: 11344697May 10, 2001Paper

Antibodies against Borrelia afzelli in patients with an early stage of Lyme disease

Wiadomości lekarskie : organ Polskiego Towarzystwa Lekarskiego
I Flisiak, B Chodynicka

Abstract

The aim of the study was evaluation of specific immune response against Borrelia afzelii in patients with erythema migrans, as a sign of an early stage of Lyme borreliosis. The study was performed in 42 patients, residents of Podlasie province, who were initially evaluated by indirect immunofluorescence assay as a seropositive for Borrelia burgdorferi sensu lato. Antibodies against particular antigens of B. afzelii were demonstrated using a Western-blot technique. Evaluation of results showed the most frequent prevalence of antibodies against 41 kDa antigen in majority of patients, which were predominantly of IgM class in patients with short-lasting lesions, and IgG class in patients with long-lasting lesions. Results of IgM blots were recognized as a positive in 26 patients, and IgG blots in 22 patients. Positive result in at least one class of antibodies was noted in 34 patients (81%), and in both classes in 14 (33%). IgM antibodies against 21 kDa antigen, and IgG antibodies against 43 kDa antigen were two fold more frequent in patients with short-lasting lesions. These results confirm the diagnostic usefulness of determination of antibodies against B. afzelii antigens in Poland. The most important for an early diagnosis can ...Continue Reading

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