Antibodies against carbamylated proteins are present in primary Sjögren's syndrome and are associated with disease severity

Annals of the Rheumatic Diseases
Brith BergumPiotr Mydel

Abstract

Herein, we investigate the presence and prognostic value of autoantibodies against carbamylated proteins (anti-CarP) in the serum of patients with primary Sjögren's syndrome (pSS). Serum levels of anti-CarP antibodies were measured in Norwegian patients with pSS (n=78) and corresponding controls (n=74) using ELISA and analysed in relation with exocrine gland function, degree of salivary gland inflammation, signs of ectopic germinal centre (GC) formation and immunological markers. For univariate comparisons, the Mann-Whitney U test and χ(2) or Fisher's exact tests were used. Correlations were assessed with Spearman's rank testing. Multivariate regression analyses were used to assess the effect of anti-CarP positivity on clinical manifestations. Of the patients with pSS, 27% were positive for anti-CarP IgG antibodies. Levels of anti-CarP correlated positively with total IgG, IgM, rheumatoid factor and β2-microglobulin. Importantly, after adjusting for confounding factors, patients positive for anti-CarP had significantly higher focus score. Furthermore, positive anti-CarP status coincided with 9.2-fold higher odds of having developed GC-like structures in the minor salivary glands. As a patient group considered having worse disea...Continue Reading

References

Oct 14, 1988·The American Journal of Medicine·R I FoxF V Howell
Jan 1, 1987·Nephron·M OimomiY Taketomi
Jan 22, 2000·Arthritis and Rheumatism·G A SchellekensW J van Venrooij
Feb 13, 2001·Kidney International. Supplement·L M Kraus, A P Kraus
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Feb 6, 2004·Journal of Biochemistry and Molecular Biology·Jawon Seo, Kong-Joo Lee
Apr 13, 2004·Arthritis and Rheumatism·Elke TheanderLennart T H Jacobsson
Feb 3, 2005·Clinical Chemistry·Eugene O ApostolovAlexei G Basnakian
Oct 7, 2005·Arthritis Research & Therapy·Annette H M van der Helm-van MilTom W J Huizinga
Sep 11, 2007·Nature Medicine·Zeneng WangStanley L Hazen
Oct 23, 2008·Scandinavian Journal of Rheumatology·E PeenH-J Haga
Jan 23, 2009·Lancet·Lars KlareskogStephen Paget
Aug 13, 2009·Autoimmunity Reviews·Gabriel J TobónAlain Saraux
Nov 6, 2009·Journal of Autoimmunity·Maria I ChristodoulouHaralampos M Moutsopoulos
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Piotr MydelMaria Bokarewa
Jul 16, 2010·European Journal of Clinical Investigation·John G Routsias, Athanasios G Tzioufas
Jan 18, 2011·Antioxidants & Redox Signaling·Michael HolzerGunther Marsche
Apr 12, 2011·Arthritis and Rheumatism·Troy E DanielsUNKNOWN Sjögren's International Collaborative Clinical Alliance Research Groups
Jun 16, 2011·Arthritis Research & Therapy·Nicolas DelaleuRoland Jonsson
Aug 2, 2011·Journal of the American Society of Nephrology : JASN·Michael HolzerGunther Marsche
Oct 4, 2011·International Immunopharmacology·Tove Ragna RekstenMalin V Jonsson
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jing ShiLeendert A Trouw
May 12, 2012·Journal of Autoimmunity·Vasiliki-Kalliopi Bournia, Panayiotis G Vlachoyiannopoulos
Sep 22, 2012·Seminars in Arthritis and Rheumatism·Anna P RisseladaJoel A G van Roon
Jan 26, 2013·Expert Opinion on Pharmacotherapy·Pilar Brito-ZerónManuel Ramos-Casals
Jul 23, 2013·Annals of the Rheumatic Diseases·P C E Hissink MullerL A Trouw
Aug 3, 2013·The Journal of Rheumatology·Efstathia K KapsogeorgouHaralampos M Moutsopoulos
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Roland JonssonGunnel Henriksson
Dec 18, 2013·Journal of Autoimmunity·Nikolaos C KyriakidisAthanasios G Tzioufas
Dec 18, 2013·Annals of the Rheumatic Diseases·Jing ShiLeendert A Trouw
May 2, 2014·Mediators of Inflammation·Agata N BurskaFrederique Ponchel
Jul 17, 2014·JAMA : the Journal of the American Medical Association·Jacques-Eric GottenbergXavier Mariette
Aug 13, 2014·Clinical Epidemiology·Ruchika Patel, Anupama Shahane
Aug 19, 2014·European Journal of Immunology·Catalin KoroPiotr Mydel

❮ Previous
Next ❯

Citations

Sep 13, 2016·Expert Opinion on Biological Therapy·Domenico SambataroRiccardo Polosa
Oct 26, 2016·JCI Insight·Sladjana SkopeljaWilliam Fc Rigby
Apr 7, 2017·Thrombosis and Haemostasis·Veronika BinderPiotr Mydel
Sep 5, 2018·European Journal of Oral Sciences·Roland JonssonKathrine Skarstein
Sep 3, 2017·The Journal of Rheumatology·M Kristen Demoruelle
May 17, 2017·The Journal of Rheumatology·Shuichiro NakaboKoichiro Ohmura
Jul 8, 2016·Nature Reviews. Disease Primers·Pilar Brito-ZerónManuel Ramos-Casals
Jul 24, 2020·Journal of Clinical Medicine·Dorian ParisisChristine Delporte
Sep 10, 2020·International Journal of Molecular Sciences·Anna WajdaAgnieszka Paradowska-Gorycka
Dec 22, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yuan ZhangLiyan Cui

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
FCS
serum collection
biopsy

Software Mentioned

Soft Max Pro
GraphPad
Prism
SAS
SPSS

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.