Antibodies against cell adhesion molecules and neural structures in paraneoplastic neuropathies

Annals of Clinical and Translational Neurology
Ana M SilesLuis Querol

Abstract

Paraneoplastic neurological syndromes (PNS) are rare neurological disorders in which ectopic expression of neural antigens by a tumor results in an autoimmune attack against the nervous system. Onconeural antibodies not only guide PNS diagnosis but may also help detecting underlying malignancies. Our project aims to uncover new potential antibodies in paraneoplastic neuropathies (PN). Thirty-four patients fulfilling diagnostic criteria of possible (n = 9; 26.5%) and definite (n = 25; 73.5%) PN without onconeural antibodies and 28 healthy controls were included in our study. Sera were tested for known antibodies against neural cell adhesion molecules and screened for novel IgG and IgM reactivities against nerve components: dorsal root ganglia (DRG) neurons, motor neurons, and Schwann cells. Patients showing autoantibodies against any of these cell types were used for immunoprecipitation (IP) studies. Overall, 9 (26.5%) patients showed significant reactivity against DRG neurons, motor neurons, or Schwann cells, whereas 5 (17.9%) healthy controls only showed moderate reactivity. Compared with control sera, serum samples from patients with paraneoplastic sensory-motor neuropathies had a higher frequency of IgM antibodies against Sc...Continue Reading

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Citations

Jul 20, 2018·The British Journal of Ophthalmology·Quangang XuShihui Wei
Mar 1, 2019·Internal and Emergency Medicine·Claudia MarinucciMaria Maddalena Zanone
Dec 4, 2020·Muscle & Nerve·Simran SawhneyGaurav Kumar Mittal
Nov 17, 2020·Frontiers in Oncology·Yumei LiangHaining Zhang
Apr 22, 2021·Brain : a Journal of Neurology·Elba Pascual-GoñiLuis Querol

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Methods Mentioned

BETA
immunoprecipitation
Fluorescence
electrophoresis
transfection

Software Mentioned

GraphPad Prism
GraphPad

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