PMID: 15228190Jul 2, 2004Paper

Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity

Scandinavian Journal of Rheumatology
M K SöderlinT Skogh

Abstract

To measure serum levels of antibodies against cyclic citrullinated peptide (anti-CCP antibodies) and serum cartilage oligomeric matrix protein (COMP) in patients with early joint inflammation, and to study the correlation of these two tests with clinical measurements. Adult patients with recent-onset arthritis, of <3 months' duration, were referred from primary healthcare centres to rheumatologists. Serum levels of anti-CCP antibodies and COMP at baseline were analysed by enzyme immunoassay (EIA) and compared with clinical baseline data. Sixty-nine patients were included. The specificity of the anti-CCP antibody test for RA was 96%, and the sensitivity was 44%. There was a significant difference between the four diagnosis groups in the anti-CCP antibody test, probability (p)<0.001, whereas no significant differences were found concerning COMP. The baseline serum COMP test correlated with age (p=0.0001), joint score for swollen joints (p=0.02), and C-reactive protein (CRP) (p=0.02). This study confirms the high diagnostic specificity of anti-CCP antibodies for rheumatoid arthritis (RA) in a prospective population-based study of very early arthritis. Raised serum COMP levels were common in all diagnosis groups in this series, ind...Continue Reading

Citations

May 10, 2005·Annals of the Rheumatic Diseases·V P K NellG Steiner
Oct 7, 2005·Arthritis Research & Therapy·Annette H M van der Helm-van MilTom W J Huizinga
Oct 20, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Antonio Fernández-SuárezAntonio Núñez
Feb 16, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Rudolf Mierau, Ekkehard Genth
Apr 16, 2005·European Journal of Immunology·Harald BurkhardtRikard Holmdahl
Oct 31, 2009·Arthritis and Rheumatism·Rohit AggarwalKaren H Costenbader
Nov 18, 2006·Autoimmunity Reviews·Walther J van VenrooijGer J M Pruijn
Jan 13, 2015·Molecular Aspects of Medicine·Michael P MorranMassimo Pietropaolo
Aug 13, 2005·Scandinavian Journal of Rheumatology·S Rantapää-Dahlqvist
Nov 1, 2006·Arthritis and Rheumatism·Tineke CantaertDominique Baeten
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Nicola Bizzaro, Marilina Tampoia
Jul 15, 2009·Clinical Rheumatology·Licia Maria Henrique da MotaJozélio Freire de Carvalho
May 4, 2007·Scandinavian Journal of Rheumatology·C NikolaisenH C Nossent
Jul 28, 2007·Scandinavian Journal of Rheumatology·E SavolainenO Kaipiainen-Seppänen
Sep 29, 2005·Rheumatology·A J W ZendmanG J M Pruijn

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