Antibodies against four proteins from a Streptococcus pyogenes serotype M1 strain and levels of circulating mannan-binding lectin in acute poststreptococcal glomerulonephritis

International Archives of Allergy and Immunology
L SkattumA G Sjöholm

Abstract

Responses against antigens from the potentially nephritogenic Streptococcus pyogenes serotype M1 in patients with acute poststreptococcal glomerulonephritis (AGN) were studied to seek indications of expression of these antigens during the preceding infection. Also, the question was asked whether the complement protein mannan-binding lectin (MBL) is required for development of the hypocomplementemia associated with AGN. Hypothetically, the lectin pathway might trigger the alternative pathway, which is consistently activated in AGN. Antibodies against three proteins associated with M1, M1 protein, streptococcal inhibitor of complement (SIC) and protein H, an IgG-binding protein, were determined by ELISA in 56 children and 17 adults with AGN. Antibodies against streptococcal cysteine proteinase, which is produced by all serotypes of S. pyogenes, were also examined. MBL concentrations were measured in the same 71 patients by a sandwich ELISA. Increased concentrations of antibodies were found against all four streptococcal proteins, albeit not uniformly distributed between different subgroups of patients. The prevalence of low MBL concentrations (<100 microg/l) including 2 patients with undetectable MBL (<10 microg/l) was similar in...Continue Reading

References

Jan 1, 1979·International Archives of Allergy and Applied Immunology·A G Sjöholm
Jun 1, 1990·Molecular Immunology·P AkessonL Björck
Feb 1, 1966·The Journal of Clinical Investigation·A F MichaelR L Vernier
Mar 6, 1999·Microbiology and Molecular Biology Reviews : MMBR·W W Navarre, O Schneewind
Feb 19, 2000·Scandinavian Journal of Infectious Diseases·A NordstrandS E Holm
Sep 2, 2000·Internal Medicine·N Yoshizawa
Aug 31, 2001·The Journal of Biological Chemistry·V RossiG J Arlaud
Dec 11, 2002·Transfusion Medicine·D C Kilpatrick
Jan 14, 2003·Annual Review of Immunology·Uffe HolmskovJens C Jensenius
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Géza AmbrusPéter Závodszky
Mar 7, 2003·The Journal of Biological Chemistry·Inga-Maria FrickLars Björck
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jaimar RinconJesus A Mosquera

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Citations

Mar 12, 2008·Current Opinion in Pediatrics·Sun-Young Ahn, Elizabeth Ingulli
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Apr 8, 2015·BMC Infectious Diseases·Mohan G KarmarkarKadaba S Sriprakash
Apr 4, 2014·Clinical Microbiology Reviews·Mark J WalkerVictor Nizet
Mar 26, 2009·Nihon saikingaku zasshi. Japanese journal of bacteriology·Yutaka Terao
May 7, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Immaculada MargaritGuido Grandi
Aug 8, 2008·Clinical and Vaccine Immunology : CVI·Virginia A F BoonRichard Speare
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez
Feb 4, 2021·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe

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