Antibodies Against GPCR.

Frontiers in Bioscience (Landmark Edition)
Carlotto Meyer, Harald Heidecke

Abstract

G-protein-coupled receptors (GPCRs) are the largest family of receptors in humans. GPCRs are seven-transmembrane receptors that are activated by the binding of a ligand to the extracellular domain. In addition to the endogenous ligands, auto-antibodies (aab) can also bind to the GPCRs. They can activate different and specific cellular pathways which contribute to various diseases. In this review, the authors summarize the knowledge about antibodies targeting GPCRs and their effects and relevance in the pathogenesis of various diseases and their use in clinical diagnostics. We highlight the role of different activating anti-GPCR aab in solid organ transplantations, stem cell transplantations, systemic sclerosis, preeclampsia, chronic fatigue syndrome, cardiovascular diseases, Alzheimer's disease, and cancer.

Citations

Jan 13, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Karin TammelinHelena Filipsson Nyström
Jan 21, 2021·The Journal of Membrane Biology·Khuraijam Dhanachandra Singh, Sadashiva S Karnik
Sep 10, 2019·Journal of the American Heart Association·William T GunningBlair P Grubb
Aug 18, 2020·Journal of the Endocrine Society·David C KemLaTasha B Craig
Aug 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Khuraijam Dhanachandra SinghSadashiva S Karnik

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