Antibodies Against Hypothalamus and Pituitary Gland in Childhood-Onset Brain Tumors and Pituitary Dysfunction.

Frontiers in Endocrinology
Giuseppa PattiNatascia di Iorgi

Abstract

Purpose: To detect the presence of antipituitary (APA) and antihypothalamus antibodies (AHA) in subjects treated for brain cancers, and to evaluate their potential association with pituitary dysfunction. Methods: We evaluated 63 patients with craniopharyngioma, glioma, and germinoma treated with surgery and/or radiotherapy and/or chemotherapy at a median age of 13 years. Forty-one had multiple pituitary hormone deficiencies (MPHD), six had a single pituitary defect. GH was the most common defect (65.1%), followed by AVP (61.9%), TSH (57.1%), ACTH (49.2%), and gonadotropin (38.1%). APA and AHA were evaluated by simple indirect immunofluorescence method indirect immunofluorescence in patients and in 50 healthy controls. Results: Circulating APA and/or AHA were found in 31 subjects (49.2%) and in none of the healthy controls. In particular, 25 subjects out of 31 were APA (80.6%), 26 were AHA (83.90%), and 20 were both APA and AHA (64.5%). Nine patients APA and/or AHA have craniopharyngioma (29%), seven (22.6%) have glioma, and 15 (48.4%) have germinoma. Patients with craniopharyngioma were positive for at least one antibody in 39.1% compared to 33.3% of patients with glioma and to 78.9% of those with germinoma with an analogous di...Continue Reading

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Citations

Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Deborah BiancoMohamad Maghnie
Mar 7, 2021·Cancers·Hugo de JongeClaudia Scotti
Mar 14, 2021·Journal of Internal Medicine·M Christ-CrainJ Refardt
Jul 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Annamaria De BellisJose G Montoya
Sep 1, 2021·Expert Review of Clinical Immunology·Francesco FrascaRosaria Maddalena Ruggeri

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