Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis

Cellular Immunology
Y KobayashiY Yoshikai

Abstract

We obtained the evidence that coadministration in vivo of mAbs against leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) suppressed the progression of experimental allergic encephalomyelitis (EAE) in rats. The suppressive effect in vivo of coadministration of the mAbs during the induction phase was not prominent, but the administration of these mAbs during the effector phase markedly suppressed the progression of clinical illness and prevented the infiltration of encephalitogenic cells into the central nervous system. However, administration of the mAb to LFA-1 alone or ICAM-1 alone did not show such suppressive effects. These findings suggest that LFA-1 and ICAM-1 are critically involved in the development of EAE and that the administration together of mAbs against adhesion molecules including LFA-1 and ICAM-1 might provide a new immunotherapeutic approach for the treatment of multiple sclerosis.

Citations

Sep 20, 2000·The Journal of Experimental Medicine·B T FifeW J Karpus
Dec 15, 2015·Stem Cell Research & Therapy·Federica BenvenutoLaura Vergani
May 26, 2007·The American Journal of Pathology·Daniel C BullardScott R Barnum
Jul 20, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sophie Desplat-JégoJosé Boucraut
Mar 1, 2002·Muscle & Nerve·Tomoko ItoTomiyasu Tsuda
Jun 21, 2005·Cellular and Molecular Neurobiology·Patric TurowskiJohn Greenwood
Jul 24, 2003·Nature Reviews. Immunology·Richard M RansohoffGrahame Kidd
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B T FifeW J Karpus
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel C BullardScott R Barnum
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·Z QingZ Fabry
Jul 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathanael D ReynoldsWilliam J Karpus
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel C BullardScott R Barnum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.