Antibodies against malondialdehyde-acetaldehyde adducts can help identify patients with abdominal aortic aneurysm

Journal of Vascular Surgery
Jeffrey S CarsonB Timothy Baxter

Abstract

Abdominal aortic aneurysm (AAA) is a pathologic dilation of the aorta. Inflammation of the aortic wall has been shown to be involved in AAA formation. Malondialdehyde-acetaldehyde (MAA) adducts are MAA/protein hybrids with immunogenic, proinflammatory, and profibrotic properties. Levels of MAA adducts are elevated in patients with coronary artery disease; however, the role of MAA adducts in AAA is unclear. We hypothesize that levels of circulating antibodies against MAA adducts are increased in patients with AAA. Plasma samples were collected from mice and patients with AAA and control patients with atherosclerosis but not AAA. AAA was induced in mice by a standard CaCl2 protocol, with matching sham mice. Plasma levels of anti-MAA antibodies were quantified by enzyme-linked immunosorbent assay. Patients with AAA exhibited higher levels of immunoglobulin G and immunoglobulin A anti-MAA antibody subtypes (P = .049 and .026, respectively) compared with control patients. Conversely, immunoglobulin M anti-MAA antibodies in AAA patients were lower compared with control patients (P = .018). In CaCl2-treated mice, immunoglobulin G anti-MAA antibodies were elevated after AAA formation (P = .006). The pattern of anti-MAA antibodies is ab...Continue Reading

References

Apr 22, 1993·The New England Journal of Medicine·C B Ernst
Nov 18, 1996·Annals of the New York Academy of Sciences·K J OzsvathM D Tilson
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·G M ThieleL W Klassen
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R RollaE Albano
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·G M ThieleN Nagata
Dec 12, 2001·The Journal of Surgical Research·V A DavisB T Baxter
Sep 5, 2002·The Journal of Clinical Investigation·G Matthew LongoB Timothy Baxter
Jun 9, 2004·International Immunopharmacology·Monte S WillisGeoffrey M Thiele
Jul 16, 2004·The Journal of Clinical Investigation·John A Curci, Robert W Thompson
Mar 1, 2005·Lancet·Tjun TangMichael Gaunt
Aug 11, 2010·Free Radical Biology & Medicine·Michael J DuryeeGeoffrey M Thiele

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Citations

Dec 24, 2017·Respiratory Research·Jill A PooleGeoffrey M Thiele
Nov 12, 2015·Biomolecules·Muna Sapkota, Todd A Wyatt
Dec 20, 2018·International Journal of Molecular Sciences·Dahn L ClemensDaniel R Anderson
Jul 30, 2021·Clinical and Translational Medicine·Laura Lopez-SanzCarmen Gomez-Guerrero
Aug 9, 2021·Free Radical Biology & Medicine·Javier Rodríguez-CarrioJosé Luis Martín-Ventura

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