PMID: 108824Mar 1, 1979

Antibodies against neurons in chronic Chagas' disease

Tropenmedizin Und Parasitologie
R Ribeiro dos SantosF Köberle

Abstract

Severe qualitative and quantitative alterations of the autonomic system inervating the heart and other organs have been demonstrated in experimental and natural Chagas' disease. These facts led us to search for the presence of antibody to neurons in 230 chagasic sera by an indirect immunofluorescence technique. Our results indicated that 83% of the chagasic patients presented IgG antibodies and 7% IgM antibodies to neurons. All control sera were negative. The demonstrated antibody to neurons presented cross-reaction against neurons of the central and peripheral nervous system (sympathetic and parasympathetic) and also against neurons of different species.

Related Concepts

Process of Absorption
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