PMID: 9654157Jul 8, 1998Paper

Antibodies against platelet glycoproteins and antiphospholipid antibodies in autoimmune thrombocytopenia

European Journal of Haematology
E LippP Berchtold

Abstract

Autoantibodies against platelet glycoproteins (anti-GP) are found in the majority of patients with autoimmune thrombocytopenia (AITP) as well as in thrombocytopenia associated with systemic lupus erythematosus (SLE). Some of these patients may have anti-phospholipid antibodies (anti-PL). To evaluate the pathogenetic significance of anti-PL and anti-GP antibodies in AITP and SLE patients, we investigated anti-cardiolipin (anti-CL), anti-phosphatidylserine (anti-PS) and anti-GP antibodies (anti-GPIIb-IIIa and anti-GPIb-IX) in 71 patients with AITP and 3 thrombocytopenic patients with SLE. Anti-GP antibodies were detected in 52 (70%) patients. Fifty-six (73%) patients showed anti-PL antibodies. Seven patients (6 AITP, 1 SLE) with both anti-GPIIb-IIIa and IgG anti-PL antibodies were followed during treatment with corticosteroids. Antibodies were measured before treatment and at the time of platelet-peak. Anti-GPIIb-IIIa antibodies decreased in all or became undetectable in five. In contrast, IgG anti-PS and IgG anti-CL antibodies decreased only moderately or remained positive. Adsorption experiments, using gelfiltered platelets, erythrocyte (Ec)-inside-out-vesicles and purified GPIIb-IIIa, showed that anti-GP and anti-PL antibodies...Continue Reading

References

Jan 1, 1991·Advances in Immunology·H P McNeilS A Krilis
May 1, 1991·British Journal of Haematology·M YanabuK Yasunaga
Nov 1, 1989·British Journal of Haematology·P BerchtoldR McMillan
Oct 1, 1988·Annals of the Rheumatic Diseases·M A KhamashtaG R Hughes
Feb 1, 1985·British Journal of Haematology·E N HarrisG R Hughes
Apr 1, 1982·Seminars in Thrombosis and Hemostasis·J G Kelton, S Gibbons
May 7, 1981·The New England Journal of Medicine·R McMillan
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester

❮ Previous
Next ❯

Citations

Mar 29, 2002·The New England Journal of Medicine·Douglas B Cines, Victor S Blanchette
Jun 24, 2006·Clinical and Experimental Immunology·P D ZiakasM Voulgarelis
Oct 16, 2007·Current Opinion in Hematology·Howard A Liebman, Roberto Stasi
Sep 9, 2010·Rheumatology·Alastair L HepburnJustin C Mason
Sep 29, 2005·Hematology·Reyhan Diz-Küçükkaya
Oct 23, 2010·Blood·Keith R McCrae
Feb 20, 2003·The American Journal of Gastroenterology·David H Van ThielNancy Leone
Apr 28, 2009·Blood·Douglas B CinesEline T Luning Prak
Oct 4, 2014·World Journal of Gastroenterology : WJG·Germán Campuzano-Maya
Sep 10, 2020·Current Anesthesiology Reports·Ingrid Moreno-Duarte, Kamrouz Ghadimi
Nov 5, 2002·Annual Review of Medicine·Jacob H Rand
May 31, 2008·British Journal of Haematology·Carole Pierrot-Deseilligny DespujolBertrand Godeau
Jun 27, 2012·Journal of Thrombosis and Thrombolysis·Rie TabataYoshio Kita
Apr 14, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Aniruddha DayamaRenu Saxena
Nov 8, 2020·Clinical Reviews in Allergy & Immunology·Huaxia YangXuan Zhang
Aug 15, 2000·Seminars in Hematology·J N GeorgeS K Vesely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.