PMID: 46713Jan 15, 1975

Antibodies against spermatozoa in infertile women with poorly invading spermatozoa on postcoital tests

American Journal of Obstetrics and Gynecology
J R WallM H Lessof

Abstract

Sixty-four women with poorly invading spermatozoa on postcoital tests (PCT's) were investigated for serum spermatozoal antibodies by the immunofluorescent technique. Control groups tested were women with explained infertility but normal PCT's, normal pregnant women, and normal previously pregnant women. A positive immunofluorescent test was obtained in 19 of 64 women with abnormal PCT's compared with 26 of 51 patients with explained infertility, including 11 of 13 who had well-identified gynecological disorders, 12 of 61 pregnant women, and one of 59 previously pregnant normal women. High titers (larger than or equal to 1/200) were found in a few patients in all groups except normal nonpregnant women. In no patient was evidence of complement fixation found. The immunofluorescent test, as carried out here, is therefore of little value in discriminating a group of patients in whom immunologic abnormalities are the primary cause of the infertility.

References

Dec 1, 1978·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W P Wong
Jan 1, 1977·British Journal of Urology·W F HendryJ Stedronska

Related Concepts

Immunofluorescence Assay
Immune System Diseases
Female Genital Diseases
Immunoglobulins
Seminal Plasma
Staining and Labeling
Muscularis Mucosae
Infertility
Y-Chromosome-Bearing Sperm
Cervix Uteri

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