PMID: 2106760Jan 1, 1990Paper

Antibodies against Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis in middle ear effusion during early phase of acute otitis media

Acta Oto-laryngologica
H KarjalainenP Sipilä

Abstract

Serum type (IgG, IgM and IgA-class) and secretory type antibodies specific to Streptococcus pneumoniae (Pn), Haemophilus influenzae (Hi) and Branhamella catarrhalis (Br) were measured by enzyme-linked immunosorbent assay (ELISA) in 46 serum and 114 middle ear effusion (MEE) samples from 85 children with acute otitis media (AOM). The samples were obtained within 12 h from the onset of the ear symptoms. Serum (but not secretory) type antibodies to the infecting Pn serotype were found in 24% of the MEE samples of the patients with Pn AOM and, correspondingly, serum and/or secretory type antibodies to Hi and Br were seen in 54% and 63% of the MEE samples of the patients with Hi or Br AOM, respectively. Moreover, antibodies against bacteria other than the causative one could also be found in the MEE. The occurrence of the serum type antibodies against these bacteria in the MEE was closely correlated with their serum levels. The findings of this study indicate that during the very early phase of AOM, the MEE contains both serum type antibodies originating from the serum, and secretory antibodies of middle ear origin. Among them there are antibodies specific to the three most common bacteria causing AOM (Pn, Hi, and Br) regardless of ...Continue Reading

References

May 1, 1985·American Journal of Otolaryngology·P KarmaH Mäkelä
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Citations

Jan 10, 2002·Clinical Microbiology Reviews·Cees M VerduinAlex van Belkum
Nov 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M SvinhufvudK Prellner
Oct 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Akkoyunlu, A Forsgren
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·L E Stenfors, S Räisänen
Jan 1, 1993·International Journal of Pediatric Otorhinolaryngology·M SvinhufvudK Prellner
Nov 11, 2006·FEMS Immunology and Medical Microbiology·Atsushi HarimayaNobuhiro Fujii
Jun 1, 1997·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Martine François
Mar 14, 2003·The Pediatric Infectious Disease Journal·Patricia Stutzmann MeierChristoph Aebi

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