Antibodies against striated muscle, connective tissue and nuclear antigens in patients with thyroid-associated ophthalmopathy: should Graves' disease be considered a collagen disorder?

Journal of Endocrinological Investigation
J KiljanskiJ R Wall

Abstract

The identity and subcellular localization of the principal extraocular muscle (EOM) antigens and prevalences of the corresponding serum autoantibodies in thyroid-associated ophthalmopathy (TAO) need to be clarified. We have used porcine eye muscle tissue, which expresses all autoantigens identified in human tissue, as substrate in an indirect immunofluorescence assay. Several different patterns of antibody binding to EOM tissue antigens were observed with sera from patients with TAO namely, membrane, cytoplasmic, interstitial (endomysial) and nuclear. Overall, sera from 75% of patients with TAO contained one or more antibodies reactive with EOM, compared to 32% of patients with Graves' hyperthyroidism, 38% with Hashimoto's thyroiditis, and 16% of normals. All sera which reacted with EOM membrane or cytoplasmic antigens also reacted with the same antigen(s) in other skeletal muscle, but not in the other tissues tested. Sera from 31% of patients with TAO, but only 7% of those with Hashimoto's thyroiditis, and no patient with Graves' hyperthyroidism without evident ophthalmopathy, contained antinuclear antibodies (ANA). The most common nuclear fluorescence pattern was the finely speckled type typically associated with anti-Sm or a...Continue Reading

References

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Citations

Oct 16, 2007·Thyroid : Official Journal of the American Thyroid Association·Teck Kim Khoo, Rebecca S Bahn
Nov 24, 1999·Thyroid : Official Journal of the American Thyroid Association·M E EvangelopoulouD A Koutras
Apr 22, 1999·Thyroid : Official Journal of the American Thyroid Association·T BednarczukJ Nauman
Feb 24, 2001·Critical Reviews in Clinical Laboratory Sciences·M YamadaJ R Wall
Aug 12, 2014·Orvosi hetilap·Annamária ErdeiV Endre Nagy
Apr 20, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·Z Kraiem, R S Newfield
May 8, 2003·Journal of the American Academy of Dermatology·Julia AiWarren R Heymann

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