Antibodies against the cancer-testis antigen CTSP-1 are frequently found in prostate cancer patients and are an independent prognostic factor for biochemical-recurrence

International Journal of Cancer. Journal International Du Cancer
Raphael B ParmigianiAnamaria A Camargo

Abstract

Cancer-testis (CT) antigens are immunogenic proteins expressed in normal gametogenic tissues and in different types of tumors. CTSP-1 is a CT antigen frequently expressed in prostate tumors, and capable of eliciting humoral response in prostate cancer patients. Here, we analyzed the presence of anti-CTSP-1 antibodies in 147 patients with localized prostate cancer and determined its prognostic value for predicting biochemical-recurrence after radical prostatectomy. Anti-CTSP-1 antibodies were detected in 25% of the patients and a significant correlation (p = 0.017) between CTSP-1 protein expression and the presence of specific humoral response was observed. No association was found between the presence of antibodies and the pathological variables analyzed. On univariate analysis, patients without antibodies against CTSP-1 had a lower biochemical-recurrence free survival than did those with anti-CTSP-1 antibodies, although the difference between the groups was not statistically significant (57 vs. 75%, p = 0.075). However, the presence of antibodies against CTSP-1 was significantly associated with a better prognosis in patients with higher Gleason score (36 vs. 80%, p = 0.028). On multivariate analysis, antibodies against CTSP-1 ...Continue Reading

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Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Raphael B ParmigianiAnamaria A Camargo

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Citations

Jun 20, 2012·Nature Reviews. Urology·Prakash KulkarniRobert H Getzenberg
Jun 30, 2009·Cancer Immunology, Immunotherapy : CII·Miriam ReuschenbachNicolas Wentzensen
Jan 15, 2011·Clinical & Developmental Immunology·Sebastian KoboldDjordje Atanackovic
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