Antibodies against the N-terminus of IL-8 receptor A inhibit neutrophil chemotaxis

Biochemical and Biophysical Research Communications
J M QuanR B Goodman

Abstract

Neutrophil migration and activation are the cornerstones of the acute inflammatory response. Interleukin-8 triggers several functions of neutrophils in host defense: chemotaxis, degranulation and enzyme release, and superoxide production. Interleukin-8 is most potent as a chemoattractant, so chemotaxis is likely the most important of these functions. The effects of interleukin-8 on neutrophils are mediated through two receptors, IL-8RA and IL-8RB. To investigate the role of these receptors in neutrophil chemotaxis, we produced inhibitory antibodies to IL-8RA. These antibodies inhibit neutrophil chemotaxis toward IL-8 in vitro. These findings show that IL-8RA mediates a chemotactic signal in neutrophils and suggest that an anti-receptor strategy may be a useful approach to limit neutrophil migration in inflammation.

Citations

Apr 7, 2009·American Journal of Respiratory Cell and Molecular Biology·Sumit BhattacharyyaJoanne K Tobacman
Mar 1, 2011·Respiratory Research·Gabriela VaccaAdrian Gillissen
Mar 31, 2009·Immunity & Ageing : I & a·Thaís Helena GasparotoVanessa Soares Lara
Mar 17, 2010·Expert Opinion on Therapeutic Targets·Bhawna SharmaRakesh K Singh
Jan 24, 2012·Expert Opinion on Biological Therapy·Mariusz Z Ratajczak, ChiHwa Kim
Sep 1, 2009·Journal of Ethnopharmacology·Ji Yun LeeChang Jong Kim
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Simona OgnjanovicGillian D Bryant-Greenwood
Oct 27, 2004·Advances in Protein Chemistry·Elaine K LauTracy M Handel
Jul 1, 2009·Journal of Leukocyte Biology·RoseMarie StillieAndrew W Stadnyk
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G GodalyC Svanborg
Aug 5, 1998·The American Journal of Physiology·R B GoodmanT R Martin
Oct 16, 2001·American Journal of Physiology. Cell Physiology·S M SeoC W Smith
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·I U SchraufstatterM Burger
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C CaraP Kubes
Mar 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Seema SinghRakesh K Singh
Mar 26, 1998·Biochemical and Biophysical Research Communications·I U SchraufstätterH Takamori
Jul 22, 1998·Journal of Immunological Methods·C W FrevertT R Martin
Dec 4, 2003·Journal of Neuroimmunology·Petra J G ZwijnenburgA Marceline van Furth
May 18, 2005·Biochemical and Biophysical Research Communications·Ru Liu-BryanDavid M Rose

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