Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes.

Journal of the American Society of Nephrology : JASN
An S DE VrieseNorbert Lameire

Abstract

Vascular endothelial growth factor (VEGF) is a cytokine that potently stimulates angiogenesis, microvascular hyperpermeability, and endothelium-dependent vasodilation, effects that are largely mediated by endothelial nitric oxide synthase (eNOS). The expression of VEGF is pronounced in glomerular visceral epithelial cells, but its function in renal physiology and pathophysiology is unknown. VEGF expression is upregulated by high ambient glucose concentrations in several cell types in vitro and in glomeruli of diabetic rats. To assess the role of VEGF in the pathophysiology of early renal dysfunction in diabetes, monoclonal anti-VEGF antibodies (Ab) were administered to control and streptozotocin-induced diabetic rats for 6 wk after induction of diabetes. Based on in vitro binding studies, an adequate serum VEGF inhibitory activity was achieved during the entire course of anti-VEGF Ab administration. Anti-VEGF Ab treatment but not administration of isotype-matched control Ab decreased hyperfiltration, albuminuria, and glomerular hypertrophy in diabetic rats. VEGF blockade also prevented the upregulation of eNOS expression in glomerular capillary endothelial cells of diabetic rats. Antagonism of VEGF had no effect on GFR and glom...Continue Reading

References

Dec 1, 1992·Kidney International·L F BrownS Rosen
Jan 1, 1994·The American Journal of Physiology·R W Van Dyke, J D Belcher
Oct 1, 1996·The Journal of Clinical Investigation·M KurokiA P Adamis
Mar 1, 1997·Journal of the American Society of Nephrology : JASN·D KoyaG L King
May 1, 1997·The Journal of Clinical Investigation·R G TiltonJ R Williamson
Mar 21, 1998·The Journal of Cell Biology·S EsserW Risau
Apr 29, 1998·The Journal of Clinical Investigation·M LuA P Adamis
Jun 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A FlyvbjergH Orskov
Apr 15, 1999·Journal of the American Society of Nephrology : JASN·G GrudenG Viberti
Oct 8, 1999·The Journal of Clinical Investigation·T OstendorfJ Floege
Nov 30, 1999·Journal of the American Society of Nephrology : JASN·Y SegevM Phillip

❮ Previous
Next ❯

Citations

Jan 24, 2002·Journal of the American Society of Nephrology : JASN·Simon C SatchellPeter W Mathieson
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Thoralf WendtAnn Marie Schmidt
May 27, 2010·The Journal of Biological Chemistry·Jianyin LongFarhad R Danesh
Apr 23, 2002·Kidney International·Bieke F SchrijversAllan Flyvbjerg
Dec 6, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A S De VrieseN H Lameire
Jan 10, 2002·Biochemical and Biophysical Research Communications·Sachi HoshiMichio Nagata
Aug 31, 2002·Diabetes/metabolism Research and Reviews·Riccardo Candido, Terri J Allen
Oct 2, 2002·Clinical Endocrinology·N García de la TorreH E Turner
Dec 13, 2002·Journal of Diabetes and Its Complications·K ShimadaT Watanabe
Dec 24, 2002·Current Opinion in Nephrology and Hypertension·Duk-Hee Kang, Richard J Johnson
Dec 25, 2002·Medicinal Research Reviews·Alexandra MartinDavid C Sane
Nov 2, 2002·Kidney International. Supplement·Hernan Rincon-CholesHanna E Abboud
Apr 17, 2003·Current Opinion in Nephrology and Hypertension·Takahiko NakagawaRichard J Johnson
Feb 27, 2021·Pharmacological Reports : PR·Gabriela ChyłaMaciej Jankowski
May 21, 2021·Life Sciences·Neha DagarSomasundaram Arumugam
Jun 13, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tsukasa NakamuraHikaru Koide
Apr 20, 2004·Current Opinion in Nephrology and Hypertension·Vera Eremina, Susan E Quaggin
Mar 30, 2004·Biochemical and Biophysical Research Communications·Akira OnozakiTsuyoshi Watanabe
Mar 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hans J BaeldeJan A Bruijn
May 20, 2004·Kidney International·Bieke F SchrijversAn S De Vriese
May 25, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·N H KimD R Cha
Jun 10, 2004·American Journal of Physiology. Renal Physiology·Takahiko NakagawaRichard J Johnson
Jul 16, 2004·Metabolism: Clinical and Experimental·Tomohito GohdaYasuhiko Tomino
Nov 6, 2004·Nephron. Physiology·Sonia J WakelinJohn L R Forsythe
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·T BabaT Watanabe
Mar 13, 2003·Kidney International·Gabriella GrudenGiancarlo Viberti
Jan 26, 2006·Journal of the American Society of Nephrology : JASN·Roy Zent, Ambra Pozzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.