PMID: 7535829Apr 1, 1995Paper

Antibodies against viral nonstructural proteins in response to infection with poliovirus

The Journal of Infectious Diseases
E EhrenfeldD F Summers

Abstract

Sera from recent and past cases of poliomyelitis as well as from healthy subjects vaccinated with live attenuated poliovirus, all contain antibodies to poliovirus nonstructural proteins. Reactivity of these antisera with nonstructural protein antigens present in virus-infected HeLa cells or translated from cDNA transcripts in rabbit reticulocyte lysates was sometimes sensitive to denaturation of the antigens. The finding of antibodies to nonstructural proteins of poliovirus and other viruses should have applications in the development of diagnostic assays for virus infection and may have implications for future vaccine design.

Citations

Sep 23, 1997·Journal of Virological Methods·L DahllundT Hyypiä
Aug 26, 2000·Virus Research·J HofmannU G Liebert
Mar 1, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M L YakovenkoV I Agol
Nov 9, 2002·FEMS Immunology and Medical Microbiology·Frank J M van KuppeveldWillem J G Melchers
Mar 25, 2010·PLoS Pathogens·Elizabeth J KellyStephen J Russell
Nov 22, 2016·Viral Immunology·Xuyan ChenJianhua Zhang

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