Antibodies contained in "M" component of some patients with multiple myeloma are directed to food antigens?

Leukemia Research
Zorica JuranicBiljana Mihaljevic

Abstract

Multiple myeloma is malignant disease that is characterized in most patients, by the presence in the serum of monoclonal gamma globulins, which in agarose gel after electrophoresis appear as protein band of restricted mobility, "M" component. The aim of this study was to determine are the antibodies contained in M-component directed to some antigen chronically present in the organism, to some of food antigens. Seventeen patients with secretory plasmacytoma were included in the study: eight of them had IgG(kappa), three had IgG(lambda), and one had biclonal IgG(kappa) and IgA(kappa), while two had IgA(kappa), the other two IgA(lambda) and one IgM(lambda) as paraproteins. M-proteins were detected analyzing patients' sera by agarose gel electrophoresis in 0.09 M barbital buffer. The each M-protein was confirmed by immunotyping (immunofixation) with corresponding antihuman antibodies directed to heavy or light chains of immunoglobulins. After the patients serum separation on agarose gel by electrophoresis, fresh 0.4% solution of crude gliadin (Sigma) in 1% SDS was put over the slides for immunoprecipitation. Preliminary results showed the interaction of gliadin with patient's serum proteins present in the protein fraction of the sa...Continue Reading

References

Dec 24, 1997·Clinical Immunology and Immunopathology·L TuckováH Tlaskalová-Hogenová
Nov 25, 2000·Journal of Autoimmunity·D SánchezH Tlaskalová-Hogenová
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ceres C RomaldiniEduardo L R Cançado
Jul 20, 2005·Best Practice & Research. Clinical Haematology·S Chen-Kiang
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Angela Dispenzieri, Robert A Kyle

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Citations

Jul 18, 2009·International Journal of Hematology·Zorica D JuranićIvana Minić
Jun 10, 2009·Expert Opinion on Drug Safety·Ulrike BacherAxel Rolf Zander

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