PMID: 11929500Apr 4, 2002Paper

Antibodies directed against nerve growth factor inhibit the acute bronchoconstriction due to allergen challenge in guinea-pigs

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A de VriesF P Nijkamp

Abstract

We have previously demonstrated that the administration of nerve growth factor (NGF) to guinea-pigs results in airway hyper-responsiveness within 1 h. In the present study we document the involvement of NGF in the acute allergic airway response. Guinea-pigs that are sensitized to ovalbumin show an acute bronchoconstriction directly after challenge with ovalbumin. Intratracheal application of 10 microg of antibodies directed against NGF (anti-NGF) 1 h before the challenge reduces the acute severe bronchoconstriction to approximately 40% and the sustained bronchoconstriction to approximately 20% of the reaction in controls. This shows a high potency of anti-NGF in diminishing the direct bronchoconstriction. Inhibition of the tyrosine kinases of the tyrosine kinase receptor A, the high-affinity receptor for NGF, has no effect on the bronchoconstriction. Therefore, we postulate that the p75, the low-affinity receptor for neurotrophins, is responsible for the acute bronchoconstriction. Our findings suggest a role for NGF in the induction of the acute asthmatic reaction. These findings offer a new potential therapeutic strategy for the treatment of allergic asthma.

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Citations

Aug 9, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yan ShiXiaohong Lv
Sep 2, 2003·Cytokine & Growth Factor Reviews·Alessandra MiceraFrancesca Levi-Schaffer
Oct 18, 2003·Cytokine & Growth Factor Reviews·Gary W Hoyle
May 15, 2007·Journal of Toxicology and Environmental Health. Part a·Yong Joo ChungMarsha D W Ward
Dec 2, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yuli LiuXiubin Fang
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Günter PäthHarald Renz
Jan 31, 2006·Respiratory Research·Cecilia KemiCaroline Olgart Höglund
Oct 13, 2009·Pharmacology & Therapeutics·Julie Nasra, Maria G Belvisi
Mar 19, 2009·Pharmacology & Therapeutics·Tibor Z VeresArmin Braun
Feb 1, 2008·Pulmonary Pharmacology & Therapeutics·Lydia Bennedich KahnCaroline Olgart Höglund
Oct 5, 2007·Pharmacology & Therapeutics·V Freund-Michel, N Frossard
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E van den WormF Engels
Mar 9, 2006·The Journal of Allergy and Clinical Immunology·Wolfgang Andreas Nockher, Harald Renz
Jul 6, 2005·European Journal of Pharmacology·Edwin van den WormFerdi Engels
Nov 9, 2005·Journal of Pharmacological Sciences·Norikazu TakanoMichio Kurachi
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Jul 22, 2006·Biochemical Society Transactions·S RochlitzerA Braun
Jun 24, 2004·Revue des maladies respiratoires·V Freund, N Frossard

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