Antibodies in autoimmune thyroiditis affect glucose metabolism of anterior cingulate

Brain, Behavior, and Immunity
Maximilian PilhatschMichael Bauer

Abstract

Hypothyroidism induced by an autoimmune process is associated with neuropsychiatric symptoms and metabolic abnormalities in the brain. The aim of this study was to examine the relationship between autoimmune thyroiditis and regional brain function in hypothyroid patients. Cerebral glucose metabolism, as an index of brain function, was assessed in regional whole-brain analyses using positron emission tomography (PET) and [18F]fluorodeoxyglucose in thirteen hypothyroid patients with autoimmune thyroiditis suffering from neuropsychiatric symptoms. The primary biological measures were radioactivity in pre-selected brain regions, relative to whole-brain radioactivity, as a surrogate index of glucose metabolism, and serum levels of thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies as endocrine markers of autoimmune thyroiditis. Serum levels of anti-TG antibodies in hypothyroid patients were significantly correlated with glucose metabolism in the perigenual anterior cingulate cortex, a brain region previously shown to regulate affect and emotional homeostasis. Thyroid autoimmune processes may play an important role in the still poorly defined pathogenic correlates of disturbed function in brain regions critically involved in ...Continue Reading

References

Aug 21, 2002·Thyroid : Official Journal of the American Thyroid Association·L A BurmeisterR D Nebes
Dec 7, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Wayne C DrevetsMarcus E Raichle
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·M Bauer, P C Whybrow
Aug 4, 2004·European Journal of Nuclear Medicine and Molecular Imaging·M PigaS Mariotti
May 6, 2006·The International Journal of Neuropsychopharmacology·Yodphat KrauszOmer Bonne
Aug 5, 2008·Journal of Neuroendocrinology·M BauerP C Whybrow
Jun 29, 2010·Behavioural Brain Research·Maximilian PilhatschGeorg Juckel
Jan 5, 2011·Journal of the Neurological Sciences·Kogie MoodleyStrinivasen Naidoo
Aug 13, 2011·Thyroid Research·Maximilian PilhatschMichael Bauer
Apr 27, 2012·Acta Psychiatrica Scandinavica·A C van de VenJ G E Janzing
Sep 11, 2012·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Christos KorosSokratis G Papageorgiou

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Citations

Feb 13, 2016·International Journal of Bipolar Disorders·Alberto BocchettaAndrea Loviselli
Jun 22, 2015·Developmental Cognitive Neuroscience·Nora C VetterMichael N Smolka
Dec 22, 2020·Frontiers in Neuroscience·Katarzyna GłombikBogusława Budziszewska

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