Antibodies in the Diagnosis, Prognosis, and Prediction of Psychotic Disorders

Schizophrenia Bulletin
Thomas A PollakPhilip McGuire

Abstract

Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the antibody repertoire. Here we review the evidence for antibodies (to self-antigens as well as infectious organism and dietary antigens) as biomarkers of diagnosis, prognosis, and treatment response in psychotic disorders. Neuronal autoantibodies have current, and increasing, clinical utility in the diagnosis of organic or atypical psychosis syndromes. Antibodies to selected infectious agents show some promise in predicting cognitive impairment and possibly other symptom domains (eg, suicidality) within psychotic dis...Continue Reading

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Citations

Nov 30, 2018·Frontiers in Psychiatry·Jaana SuvisaariTuukka T Raij
Apr 6, 2019·Frontiers in Psychiatry·Rose Jeppesen, Michael Eriksen Benros
Feb 28, 2021·NPJ Schizophrenia·Rajendran RameshA S Kamalanathan
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Aug 19, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·T P KlyushnikL V Androsova

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay
pharmacotherapy

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