Antibodies to amino acid 200-239 (p200) of Ro52 as serological markers for the risk of developing congenital heart block.

Clinical and Experimental Immunology
Linn StrandbergMarie Wahren-Herlenius

Abstract

Maternal autoantibodies to the p200-epitope of Ro52 have been suggested to correlate with development of congenital heart block. The aim of the present study was to evaluate the clinical relevance and predictive value of p200-antibodies in high-risk pregnancies. Sera from 515 Finnish, Swedish and American women were included in the study. Sera originated from 202 mothers with an infant affected by second- or third-degree atrioventricular block (AVB), 177 mothers with rheumatic disease having infants with normal heart rate and female blood donors (n = 136). A novel serological assay for Ro52 p200-antibodies with intra- and inter-assay variability of 3% and 3.8% respectively was developed. Mothers of children affected by AVB II-III had significantly higher p200-antibody levels than mothers with rheumatic disease having children with normal heart rate (P < 0.001). In the Swedish cohort, a distinction between foetuses with normal conduction, AVB I, AVB II and III was possible. A significant difference in anti-p200 levels between AVB I and AVB II-III groups compared with foetuses with normal conduction (P < 0.05 and P < 0.01) was observed. Using p200-antibodies as a second step analysis in Ro52-positive pregnancies increased the pos...Continue Reading

Associated Clinical Trials

References

Dec 1, 1988·British Heart Journal·M V MachadoL D Allan
Jun 1, 1995·Clinical and Experimental Immunology·E D SilvermanK B Elkon
Apr 1, 1994·Annals of Internal Medicine·J Waltuck, J P Buyon
Oct 1, 1993·Lupus·J P Buyon
Jul 13, 2002·Arthritis and Rheumatism·Stina SalomonssonMarie Wahren-Herlenius
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Hiroshi YoshidaToshihiko Nagai
Apr 13, 2004·Arthritis and Rheumatism·Sven-Erik SonessonMarie Wahren-Herlenius
Sep 16, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Robert M Clancy, Jill P Buyon
Jan 5, 2005·The Journal of Experimental Medicine·Stina SalomonssonMarie Wahren-Herlenius
Apr 23, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marie-Josée RaboissonSylvie Gamache
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Jill P Buyon, Robert M Clancy
Oct 3, 2006·Current Opinion in Immunology·Marie Wahren-Herlenius, Sven-Erik Sonesson
Feb 9, 2007·Clinical and Experimental Immunology·J H ReedT P Gordon

❮ Previous
Next ❯

Citations

Dec 17, 2009·Clinical Reviews in Allergy & Immunology·Antonio BrucatoJill Buyon
May 2, 2012·Arthritis Research & Therapy·Aurélie Ambrosi, Marie Wahren-Herlenius
Mar 26, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hisaaki AokiFutoshi Kayatani
Aug 11, 2010·Scandinavian Journal of Immunology·S Salomonsson, L Strandberg
Aug 6, 2011·Scandinavian Journal of Immunology·S SalomonssonM Wahren-Herlenius
Aug 11, 2010·Scandinavian Journal of Immunology·P E LazzeriniF Laghi-Pasini
Jan 18, 2014·Experimental Cell Research·Aurélie AmbrosiMarie Wahren-Herlenius
May 4, 2010·American Journal of Obstetrics and Gynecology·Yvan MivelazJean-Claude Fouron
Dec 30, 2011·Journal of Autoimmunity·Laura AndreoliAngela Tincani
Aug 10, 2010·Lupus·L A Lee
Jan 15, 2016·Lupus·P Brito-ZerónM A Khamashta
Jul 7, 2009·Lupus·R KlauningerMarie Wahren-Herlenius
May 19, 2017·Current Opinion in Rheumatology·Peter IzmirlyJill P Buyon
Jan 6, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Elena MattiaAmelia Ruffatti
Apr 14, 2020·Prenatal Diagnosis·Meghana A LimayeShilpi S Mehta-Lee
Mar 25, 2015·Nature Reviews. Rheumatology·Pilar Brito-ZerónMunther A Khamashta
Aug 1, 2013·Auto- Immunity Highlights·Konstantin N KonstantinovRobert L Rubin
Nov 15, 2020·Scandinavian Journal of Immunology·Aurelie AmbrosiMarie Wahren-Herlenius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.