PMID: 15384504Sep 24, 2004Paper

Antibodies to Aqx toxin of Actinobacillus equuli in horses and foals

The Veterinary Record
Hélène BerthoudPeter Kuhnert

Abstract

Actinobacillus equuli is found in the normal oral flora of horses, but has been associated with several diseases, and particularly with the usually fatal septicaemia in neonatal foals which is thought to be associated with a failure of the passive transfer of immunoglobulins via the colostrum. The Aqx protein of A equuli, belonging to the RTX family of pore-forming toxins, is also cytotoxic to horse lymphocytes. The presence of antibodies to Aqx was investigated in sera from individual horses from different regions; the sera from adult horses and foals 24 hours after birth reacted with Aqx, and sera from foals sampled shortly after an intake of colostrum also reacted with Aqx, but sera from foals taken before an intake of colostrum did not react with Aqx.

References

Mar 20, 1976·The Veterinary Record·B H KimJ G Atherton
Jun 1, 1992·Infection and Immunity·L L Burrows, R Y Lo
May 1, 1985·Equine Veterinary Journal·L B Jeffcott
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Apr 1, 1996·Australian Veterinary Journal·A L RaisisD R Hodgson
Oct 17, 1998·The Veterinary Record·A N RycroftA Bjornson
Jan 21, 2000·The Veterinary Journal·A N Rycroft, L H Garside
Jun 1, 2000·Veterinary Microbiology·A SchallerJ Frey

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