Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection

The New England Journal of Medicine
G MillerP Moore

Abstract

The recent identification in patients with Kaposi's sarcoma of DNA sequences with homology to gammaherpesviruses has led to the hypothesis that a newly identified virus, Kaposi's sarcoma-associated herpeslike virus (KSHV), has a role in the pathogenesis of Kaposi's sarcoma. We developed serologic markers for KSHV infection. KSHV antigens were prepared from a cell line (BC-1) that contains the genomes of both KSHV and the Epstein-Barr virus (EBV). We used immunoblot and immunofluorescence assays to examine serum samples from 102 patients with human immunodeficiency virus type 1 (HIV-1) infection for antibodies to KSHV-associated proteins and to distinguish these antibodies from antibodies to EBV antigens. A positive serologic response was defined by the recognition of an antigenic polypeptide, p40, in n-butyrate-treated BC-1 cells and by the absence of p40 recognition in untreated BC-1 cells or EBV-infected, KSHV-negative cells. The detection by the immunofluorescence assay of 10 to 20 times more antigen-positive cells in n-butyrate-treated BC-1 cells than in untreated cells was considered a positive response. Antibodies to the p40 antigen expressed by chemically treated BC-1 cells were identified in 32 of 48 HIV-1-infected pati...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1992·Journal of Virology·J C AlbrechtB Fleckenstein
Feb 29, 1992·Lancet·Y Q HuangA E Friedman-Kien
Jan 1, 1991·Health Affairs·M V PaulyJ Hoff
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A CalenderG M Lenoir
Jul 1, 1987·The Journal of Infectious Diseases·R F AmbinderP B Wright
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Miller, M Lipman
Jul 15, 1980·International Journal of Cancer. Journal International Du Cancer·G GiraldoE S Huang
Jun 1, 1982·Annals of Internal Medicine·A E Friedman-KienS Zolla-Pazner
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M RabsonG Miller
Jul 1, 1995·Nature Medicine·M SchallingP Biberfeld
Jul 1, 1993·Journal of Virology·W M van GrunsvenJ M Middeldorp
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Oct 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R Y WangR K Mayur
Feb 12, 1993·Science·N LisitsynM Wigler

❮ Previous
Next ❯

Citations

Dec 16, 1997·The Prostate·R MunkerH P Koeffler
Jan 13, 2006·Journal of Molecular Histology·Omar BagasraCharles Wood
Oct 1, 1996·Trends in Microbiology·M K Offermann
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bhavna H ChohanRhoda Ashley Morrow
Aug 31, 1996·Lancet·T F SchulzR A Weiss
Feb 1, 1997·Journal of Virological Methods·M J LockV C Emery
Aug 2, 2003·Cancer Letters·A ZafiropoulosD A Spandidos
Jan 5, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·K H Antman
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G NastiU Tirelli
Jul 11, 1998·Oral Oncology·S R PorterN Kumar
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·D C EdelmanN T Constantine
Nov 26, 2010·Nature Reviews. Cancer·Patrick S Moore, Yuan Chang
Dec 11, 1999·Proceedings of the Association of American Physicians·W A Blattner
Dec 11, 1999·Proceedings of the Association of American Physicians·F NeipelB Fleckenstein
Sep 12, 1996·The New England Journal of Medicine·J N MartinD H Osmond
Apr 6, 2000·The New England Journal of Medicine·K Antman, Y Chang
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·R SunG Miller
Aug 1, 1997·AIDS Patient Care and STDs·J L Helton
Nov 5, 1999·Current Opinion in Oncology·J N Martin, D H Osmond
Apr 6, 2001·Sexually Transmitted Diseases·C DiamondUNKNOWN Seattle Young Men's Survey Team
Jan 25, 2003·Current Opinion in Pediatrics·Hal B Jenson
Nov 19, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Moraima GuadalupeShou-Jiang Gao
Oct 24, 2008·Transplantation·Ahmed F DoniaMohamed A Ghoneim
May 1, 1997·Oral Diseases·C BoshoffR A Weiss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.