Antibodies to Campylobacter flagellin recognize epitopes common to phase 1 and phase 2 flagella.

Research in Microbiology
M KirimatP M Martin

Abstract

We used a simple method to obtain purified flagellin from Campylobacter, suitable for an immunization procedure in mice. Western blot analysis of cross-reacting antibodies showed that there were epitopes common to phase 1 and 2 flagellins. Analysis by ELISA suggested that certain common flagellar epitopes are conformational, and antibody immobilization tests confirmed that common surface-exposed epitopes exist in a region of flagella necessary for conferring motility to the bacteria.

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Citations

Jan 1, 1992·Research in Microbiology·G RenomP M Martin

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