PMID: 9431591Feb 7, 1998Paper

Antibodies to cytokeratins in inflammatory arthropathies

Seminars in Arthritis and Rheumatism
A A Borg

Abstract

Cytokeratins are a major constituent of the cytoskeleton in eukaryotic cells and are vital for the maintenance of cell structure and function. Identification of increased levels of IgA antibodies to these intracellular structures has prompted increasing interest in the potential role between the gut and the immune system in the pathogenesis of inflammatory arthritis. This review examines the salient features of cytokeratin (CK) antibodies that are relevant to inflammatory arthropathies and discusses the meaning and potential applications of these findings in the context of the different arthropathies. Review of the literature on antibodies to cytokeratins in inflammatory arthropathies, using MEDLINE and the key words (cyto)keratin and arthritis. The studies were interpreted and critiqued. Increased levels of IgA antibodies to CK-18 and epidermal keratins have been shown by enzyme-linked immunosorbent assay (ELISA) in rheumatoid arthritis and psoriatic arthritis. Levels were not increased in osteoarthritis or reactive arthritis. CK-18 is present within endothelial cells lining synovial blood vessels in patients with various rheumatic conditions, including rheumatoid arthritis, as well as in normal controls. Damage to synovial en...Continue Reading

References

Apr 1, 1992·Annals of the Rheumatic Diseases·K R RogersD R Blake
Jan 1, 1987·Scandinavian Journal of Rheumatology·H Kirstein, F K Mathiesen
Jan 1, 1988·Acta histochemica·M KasperU Karsten
Feb 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H KirsteinT M Hansen
Apr 1, 1988·Annals of the Rheumatic Diseases·P Venables
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C CzerkinskyJ Mestecky
Jun 1, 1981·Annals of the Rheumatic Diseases·D L ScottK W Walton
Jun 1, 1994·Annals of the Rheumatic Diseases·A A BorgD L Mattey

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Citations

Jan 1, 2005·Journal of the American Academy of Dermatology·Philip Mease, Bernard S Goffe
Jan 17, 2002·Rheumatology·U LindqvistG Michaëlsson
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Srimoyee GhoshBrigitte T Huber

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