Antibodies to cytoskeletal proteins in patients with Crohn's disease

European Journal of Clinical Investigation
W J MayetK H Meyer zum Büschenfelde

Abstract

The immunologic basis of inflammatory bowel disease has been the focus of interest of a series of studies on Crohn's disease and the process of immune sensitization at the gastrointestinal mucosal level is functionally poorly understood. To date only few contradictory reports concerning the incidence of autoantibodies in patients with this disease exist. The aim of this study was to investigate the sera drawn from 60 patients suffering from biopsy-proven Crohn's disease to evaluate the prevalence of autoantibodies against nuclear antigens and cytoskeletal proteins. Using standard methods, no anti-nuclear antibodies or antibodies to extractable nuclear antigens could be detected. All sera were also negative for antibodies to double-stranded DNA, anti-mitochondrial antibodies, and antibodies to gastric parietal cells. Using sensitive enzyme-linke immunosorbent assays with purified antigens and Western blotting with cytoskeletal proteins of human intestinal cells, the following antibodies could be demonstrated: cytokeratin 18 autoantibodies (IgG 20.0%; IgM 6.7%; IgA 13.3%), actin antibodies (IgG 36.7%; IgM 48.3%, IgA 26.7%), desmin antibodies (IgG 6.7%; IgM 15.08%; IgA 5.0%), vimentin antibodies (IgG 3.3%; IgM 16.7%; IgA 10.0%) an...Continue Reading

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Citations

Mar 4, 1998·Journal of Clinical Laboratory Analysis·J StreicherP M Bayer
Dec 12, 2007·Inflammatory Bowel Diseases·Toshio SakiyamaHirohito Tsubouchi
May 2, 2002·Clinical and Experimental Immunology·L Kazemi-ShiraziR Valenta
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Jan 21, 2014·Environmental Science and Pollution Research International·Daniela BatistaNorbert F Miekeley

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