Antibodies to filamentous actin (F-actin) in type 1 autoimmune hepatitis

Journal of Clinical Pathology
Alessandro GranitoF B Bianchi

Abstract

To evaluate the diagnostic significance of anti-filamentous actin antibodies (A-FAA) assessed with a commercial ELISA in comparison with immunofluorescence reactivity and patterns of anti-smooth muscle antibodies (SMA); and to correlate A-FAA positivity with clinical, immunogenetic, laboratory, and histological features in patients with autoimmune hepatitis type 1 (AIH-1). We studied 78 consecutive untreated AIH-1 patients and 160 controls: 22 with autoimmune hepatitis type 2 (AIH-2), 51 with hepatitis C, 17 with coeliac disease (CD), 20 with primary biliary cirrhosis (PBC) and 50 blood donors. SMA was evaluated by indirect immunofluorescence (IIF) on frozen sections of rat tissues, and A-FAA with a modified commercial ELISA. SMA was detected by IIF in 61 (78%) of 78 AIH-1 patients, of whom 47 (60%) had the SMA-T/G and 14 (18%) the SMA-V pattern. Of the pathological controls, 32 (20%) had the SMA-V pattern (25 with hepatitis C, 2 with AIH-2, 2 with PBC, 3 with CD). A-FAA were present in 55 AIH-1 patients (70.5%; 46 with SMA-T/G, 7 with SMA-V, and 2 SMA-negative), and in 10 controls (6%), of whom five had hepatitis C, two AIH-2, two PBC and one CD. The association between A-FAA and the SMA-T/G pattern was statistically significa...Continue Reading

References

May 1, 1976·Journal of Clinical Pathology·G F BottazzoU Groeschel-Stewart
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E L CançadoA A Laudanna
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J CzajaF B Bianchi
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F CassaniF B Bianchi
Sep 5, 2001·Journal of Clinical Pathology·R A Silvestrini, E M Benson
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Albert J CzajaUNKNOWN American Association for the Study of Liver Disease
May 27, 2003·Autoimmunity·Paolo MuratoriFrancesco B Bianchi
Oct 7, 2004·Journal of Hepatology·Diego VerganiUNKNOWN International Autoimmune Hepatitis Group

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Citations

Sep 27, 2006·Journal of Clinical Immunology·Paul GuéguenYves Renaudineau
Jan 6, 2011·Clinical Reviews in Allergy & Immunology·Diego Vergani, Giorgina Mieli-Vergani
Sep 11, 2013·Journal of Autoimmunity·Rodrigo LiberalDiego Vergani
Apr 7, 2007·Current Opinion in Gastroenterology·Albert J Czaja
Jan 11, 2007·Journal of Clinical Pathology·C LiaskosG N Dalekos
Jun 6, 2008·World Journal of Gastroenterology : WJG·Edward-L Krawitt
Jun 6, 2008·World Journal of Gastroenterology : WJG·Dimitrios-P BogdanosDiego Vergani
Jun 18, 2009·Seminars in Immunopathology·Diego VerganiGiorgina Mieli-Vergani
May 14, 2010·Digestive Diseases and Sciences·Albert J Czaja
Dec 22, 2011·Digestive Diseases and Sciences·Albert J Czaja
Oct 1, 2007·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Dec 30, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesca MarcianoPietro Vajro
Sep 23, 2014·Journal of Clinical Laboratory Analysis·Danilo VillaltaUNKNOWN Study Group on Autoimmune Diseases of the Italian Society of Laboratory Medicine, Italy
Dec 31, 2011·Clinics and Research in Hepatology and Gastroenterology·Catherine Johanet, Eric Ballot
Jul 28, 2010·American Journal of Clinical Pathology·Rachel M HudackoRhonda K Yantiss
Jan 19, 2011·Autoimmunity Reviews·Katerina G OikonomouGeorge N Dalekos
Jul 10, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luigi MuratoriMarco Lenzi
May 11, 2010·Gastroenterology·Albert J Czaja, Michael P Manns
Dec 10, 2008·Journal of Molecular Biology·Ulrich SchroederCora-Ann Schoenenberger
Mar 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Albert J Czaja
Sep 23, 2008·Journal of Clinical Laboratory Analysis·Vincent AubertFrançois Spertini
May 9, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Teru KumagiJenny Heathcote
Oct 13, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ian R Mackay
Jul 11, 2007·Journal of Clinical Laboratory Analysis·Troy D JaskowskiHarry R Hill
Nov 5, 2011·Alimentary Pharmacology & Therapeutics·K ZachouG N Dalekos
Jun 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Daijun XiangHuiping Yan
Jan 8, 2013·Journal of Clinical Laboratory Analysis·B PorcelliL Terzuoli
Sep 10, 2013·Alimentary Pharmacology & Therapeutics·K ZachouL Muratori
Nov 27, 2014·Journal of Clinical Laboratory Analysis·Heiko SchotteBernhard Schlüter
Aug 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Claudia A CoutoEduardo L R Cançado
Feb 24, 2009·Autoimmunity Reviews·A SoaresH Ribeiro
Sep 6, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jun 2, 2015·Frontiers in Immunology·Eduardo Luiz Rachid CancadoDebora Raquel B Terrabuio
Nov 15, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Konstantinos P MakaritsisGeorge N Dalekos
May 25, 2016·Expert Review of Gastroenterology & Hepatology·Rodrigo LiberalDiego Vergani
Aug 22, 2014·European Journal of Gastroenterology & Hepatology·Douglas GrunwaldRaza Malik
May 10, 2017·Expert Review of Clinical Immunology·Paolo MuratoriLuigi Muratori
May 11, 2007·The American Journal of Gastroenterology·Alessandro GranitoFrancesco B Bianchi
Feb 23, 2017·World Journal of Gastroenterology : WJG·Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon
Jul 9, 2016·International Journal of Surgical Pathology·Suvradeep Mitra, Ranjana Walker Minz

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