PMID: 3761105Sep 1, 1986Paper

Antibodies to gliadin by ELISA as a screening test for childhood celiac disease

Journal of Pediatric Gastroenterology and Nutrition
M R StåhlbergM Viander

Abstract

The sera of 309 children who were subjected to jejunal biopsy were tested for antigliadin antibodies (AGA) with enzyme-linked immunosorbent assay (ELISA) in order to evaluate the usefulness of this test as a screening test for childhood celiac disease (CD). Thirty-one children had flat intestinal mucosa later confirmed to be due to CD. Ninety percent of these children had significantly elevated levels of IgA class AGA and 94% had significantly elevated levels of IgG class AGA as compared to standard references. Two hundred and seventy-eight children had normal villous structure. In this group, 37 children out of 271 (seven excluded because of selective IgA deficiency) had elevated levels of IgA class AGA, and 93 children out of 278 had elevated levels of IgG class AGA. We conclude that ELISA-AGA is suitable as a screening test for childhood CD.

Citations

Nov 1, 1988·European Journal of Pediatrics·S KoletzkoU Wendel
Jun 1, 1991·Digestive Diseases and Sciences·U VoltaF B Bianchi
Jun 2, 1990·Lancet·D E LoftP T Crowe
Jul 3, 1998·Gastroenterology Clinics of North America·V Nehra
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ujjal PoddarKartar Singh
May 26, 1999·Australian and New Zealand Journal of Medicine·A MillerA d'Apice
Dec 1, 1991·Acta paediatrica Scandinavica·J RautonenE Savilahti
May 1, 1996·Acta Paediatrica. Supplement·K Pittschieler, B Ladinser
Sep 10, 2003·Pathology·Richard C W WongStephen Adelstein
Jun 1, 1995·Baillière's Clinical Gastroenterology·M Mäki
Jul 1, 1991·Clinics in Dermatology·E H BeutnerV Kumar
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