Antibodies to histones and histone-histone complexes: immunochemical evidence for secondary structure in histone 1

N MihalakisB F Erlanger


Highly specific antibodies were raised to histone 1 (H 1) and the histone complexes H32-H42 AND H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in acid- or urea-treated H1. The antibodies showed different reactivities with chromosomes as compared to antibodies in acid-extracted histones and should be useful in studies of native chromatin and chromosome structure.


Apr 22, 1975·Biochemistry·D Goldblatt, M Bustin
May 6, 1975·Biochemistry·E M BradburyP Sautiere
May 1, 1974·Experimental Cell Research·D E Comings, E Avelino
Apr 26, 1972·Biochimica Et Biophysica Acta·A B Barclay, R Eason
Feb 26, 1974·Biochemistry·K WakabayashiL S Hnilica
Nov 19, 1974·Biochemistry·J A D'Anna, I Isenberg
Nov 1, 1972·FEBS Letters·B A NoirA O Stoppani
May 24, 1974·Science·R D Kornberg, J O Thomas
Jul 24, 1974·Biochemical and Biophysical Research Communications·D E RoarkG H Keller
Jun 18, 1968·Biochimica Et Biophysica Acta·E D WhittleV R Potter
Mar 1, 1969·Archives of Biochemistry and Biophysics·S Panyim, R Chalkley
Sep 1, 1969·The Biochemical Journal·P A Ewars, K V Sooter
May 20, 1971·FEBS Letters·D R. van der Westhuyzen, C von Holt


Aug 1, 1989·Molecular Immunology·M MonestierL Böhm
Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P Martínez, J Palau
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C E ShayJ M Neelin
Jul 1, 1980·European Journal of Biochemistry·C MuraM Champagne
Sep 1, 1978·The Journal of Clinical Investigation·M J Fritzler, E M Tan
Sep 15, 1977·FEBS Letters·D Absolom, M H Van Regenmortel
Oct 12, 1981·FEBS Letters·S H BrandI O Walker
Jan 1, 1984·European Journal of Immunology·R LaskovD Eilat
Jun 14, 1977·Biochemistry·L Feldman, B D Stollar
Nov 10, 1981·Biochemistry·N V BeaudetteG D Fasman

Related Concepts

Antibody Specificity
Histone H7
Hydrogen-Ion Concentration

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.