Antibodies to human optic nerve in Leber's hereditary optic neuropathy

Journal of the Neurological Sciences
P R SmithA H Schapira

Abstract

Mutations of mitochondrial DNA have now been identified in the majority of patients with Leber's hereditary optic neuropathy (LHON). However, these mutations do not explain all the clinical features of LHON, and other pathogenetic factors are likely to be operating. We have analysed serum from 69 LHON patients and their relatives, 58 controls and 14 patients with ischemic or compressive optic neuropathy. A significant proportion of LHON patients had circulating antibodies to tubulin protein. This finding supports the theory that autoimmunity may play some role in the pathogenesis of LHON.

References

Sep 1, 1994·Survey of Ophthalmology·N Swartz, P J Savino
Mar 1, 1994·Journal of the Neurological Sciences·P R SmithA H Schapira
Dec 15, 1993·American Journal of Ophthalmology·Y MashimaN Shimizu

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Citations

Aug 1, 1996·Annals of Neurology·R M ChalmersA E Harding
Apr 26, 2006·Current Neurology and Neuroscience Reports·Bernadette Kalman
Feb 1, 1996·Journal of the Neurological Sciences·R M ChalmersA E Harding
Sep 1, 1996·Journal of the Neurological Sciences·B KalmanH Alder
Feb 16, 2000·Lancet·J V Leonard, A H Schapira
Jan 5, 2002·Ophthalmology·John B KerrisonRenata M Engler
Mar 23, 2011·Molecular & Cellular Proteomics : MCP·Krishnakumar N MenonClaude C A Bernard
Jul 13, 2004·The Neurologist·Bernadette Kalman, Thomas P Leist
Nov 13, 2008·Journal of Medical Genetics·P Yu-Wai-ManP F Chinnery
Mar 19, 2002·Journal of Medical Genetics·P Yu-Wai-ManP F Chinnery
Aug 12, 2014·Autoimmunity Reviews·Judith FraussenVeerle Somers
Jun 4, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tamara Vyshkina, Bernadette Kalman
Dec 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L I Grossman, E A Shoubridge
Jan 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·B KalmanH Alder
Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bénédicte CauweGhislain Opdenakker
Apr 1, 1996·Multiple Sclerosis : Clinical and Laboratory Research·B KalmanD Chatterjee
Mar 17, 1999·Biochimica Et Biophysica Acta·R M Chalmers, A H Schapira

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